Overview
Bioavailable resveratrol analog with longer half-life.
- Blueberries
- Grapes
- Pterostilbene capsule
Forms & variants of Pterostilbene
Different chemical forms of Pterostilbene behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Similar to resveratrol but better bioavailability and SIRT1 activation.
- · SIRT1 activation
Effects on the body
Organ system effects
Pterostilbene acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Pterostilbene supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Evidence-based benefits
May raise LDL at higher doses (paradox)
Limited evidencePotential side effects
- · Pterostilbene is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Pterostilbene — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Pterostilbene third party tested NSF
CapsulesPre-measured Pterostilbene capsules — easiest for travel and consistent daily dosing without scoops or scales.Pterostilbene capsules
PowderBulk unflavored Pterostilbene powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Pterostilbene powder unflavored
Best sellersMost-purchased Pterostilbene products on Amazon — a quick way to see what's reviewed widely before you commit.Pterostilbene best sellerScientific evidence8Show studiesHide studies
Pterostilbene on cholesterol and blood pressure
Riche DM, et al.
6-8 week RCT of pterostilbene 250 mg/d.
Reduced BP; modest LDL increase at higher doses.
PubMed: Pterostilbene — May raise LDL at higher doses
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PubMed: Pterostilbene — randomized controlled trial
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PubMed: Pterostilbene — meta-analysis
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PubMed: Pterostilbene — pharmacokinetics
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PubMed: Pterostilbene — safety adverse events
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PubMed: Pterostilbene — dose response
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Google Scholar: Pterostilbene — clinical evidence
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Cross-database citation index for Pterostilbene as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.