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evidence · mechanism · dose
Supplements/Vitamin

Niacin Extended Release

Slow-release nicotinic acid for cholesterol.

Cardiovascular Health

Overview

Slow-release nicotinic acid for cholesterol.

Natural sources
    Common forms

      Mechanism of action

      Inhibits hepatic VLDL synthesis; raises HDL.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Raises HDL 15–35%

        Moderate evidence

        Potential side effects

        Common
        • · Flushing
        • · Hepatotoxicity
        • · Glucose intolerance
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–2000 mg at bedtime

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTNEJM · 2011

            Niacin AIM-HIGH

            AIM-HIGH Investigators

            3414 statin-treated patients

            Key findings

            No additional CV event reduction over statin alone.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacin Extended Release — Raises HDL 15–35%

            Live PubMed search

            Live results for "Niacin Extended Release Raises HDL 15–35%" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacin Extended Release and "Raises HDL 15–35%". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacin Extended Release — randomized controlled trial

            Live PubMed search

            Live results for "Niacin Extended Release randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacin Extended Release and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacin Extended Release — meta-analysis

            Live PubMed search

            Live results for "Niacin Extended Release meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacin Extended Release and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacin Extended Release — pharmacokinetics

            Live PubMed search

            Live results for "Niacin Extended Release pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacin Extended Release and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacin Extended Release — safety adverse events

            Live PubMed search

            Live results for "Niacin Extended Release safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacin Extended Release and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacin Extended Release — dose response

            Live PubMed search

            Live results for "Niacin Extended Release dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacin Extended Release and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Niacin Extended Release — clinical evidence

            Live Scholar search

            Cross-database citation index for Niacin Extended Release as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.