Overview
Slow-release nicotinic acid for cholesterol.
- Whole-food sources (animal products for fat-soluble and B-complex vitamins; produce for water-soluble vitamins)
- Fortified foods (cereals, dairy, plant milks, nutritional yeast)
- Multivitamins or stand-alone supplements in synthetic or food-derived form
- Capsule or softgel
- Sublingual tablet or liquid
- Methylated active form for sensitive individuals
- Multivitamin matrix
Mechanism of action
Inhibits hepatic VLDL synthesis; raises HDL.
- · Inhibits hepatic VLDL synthesis
- · raises HDL
Effects on the body
Organ system effects
Niacin Extended Release supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Evidence-based benefits
Raises HDL 15–35%
Moderate evidencePotential side effects
- · Flushing
- · Hepatotoxicity
- · Glucose intolerance
Drug interactions
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Niacin Extended Release — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Niacin Extended Release third party tested NSF
CapsulesPre-measured Niacin Extended Release capsules — easiest for travel and consistent daily dosing without scoops or scales.Niacin Extended Release capsules
PowderBulk unflavored Niacin Extended Release powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Niacin Extended Release powder unflavored
Best sellersMost-purchased Niacin Extended Release products on Amazon — a quick way to see what's reviewed widely before you commit.Niacin Extended Release best sellerScientific evidence8Show studiesHide studies
Niacin AIM-HIGH
AIM-HIGH Investigators
3414 statin-treated patients
No additional CV event reduction over statin alone.
PubMed: Niacin Extended Release — Raises HDL 15–35%
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PubMed: Niacin Extended Release — dose response
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