Overview
Polyphenol-rich fruit converted by gut microbes to urolithin A (mitochondrial benefit).
- Punica granatum
- Juice
- Punicalagin standardized
- Urolithin A direct
Mechanism of action
Punicalagins are converted to urolithin A, inducing mitophagy.
- · Mitophagy
- · Antioxidant
Effects on the body
Organ system effects
Reduces carotid IMT progression.
Evidence-based benefits
Improves endothelial function & carotid IMT
Moderate evidenceImproves muscle endurance (urolithin A)
Moderate evidencePotential side effects
- · Pomegranate is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Bleeding disorders
- ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
- ·Discuss stopping ≥2 weeks before scheduled surgery.
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Pomegranate — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Pomegranate third party tested NSF
CapsulesPre-measured Pomegranate capsules — easiest for travel and consistent daily dosing without scoops or scales.Pomegranate capsules
PowderBulk unflavored Pomegranate powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Pomegranate powder unflavored
Best sellersMost-purchased Pomegranate products on Amazon — a quick way to see what's reviewed widely before you commit.Pomegranate best sellerScientific evidence9Show studiesHide studies
Pomegranate juice on carotid intima-media thickness
Aviram M, et al.
3-year trial of pomegranate juice in patients with carotid stenosis.
Reduced carotid IMT by up to 30% and lowered BP.
PubMed: Pomegranate — Improves endothelial function & carotid IMT
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PubMed: Pomegranate — Improves muscle endurance
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PubMed: Pomegranate — randomized controlled trial
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PubMed: Pomegranate — safety adverse events
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PubMed: Pomegranate — dose response
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Google Scholar: Pomegranate — clinical evidence
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