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evidence · mechanism · dose
Supplements/Herb

Olive Leaf Extract

aka Oleuropein

Mediterranean herb with antihypertensive and immune effects.

Cardiovascular HealthImmune FunctionBlood Sugar Management

Overview

Mediterranean herb with antihypertensive and immune effects.

Natural sources
  • Olea europaea leaf
Common forms
  • Standardized oleuropein

Mechanism of action

Oleuropein and hydroxytyrosol inhibit ACE and provide antioxidant effects.

Pathways
  • · ACE inhibition
  • · Antioxidant

Effects on the body

Decreases
Blood pressure
Decreases
LDL oxidation

Organ system effects

Cardiovascular

Lowers BP comparable to captopril (small RCT).

Evidence-based benefits

Reduces BP in pre-hypertensives

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Antihypertensives
      Additive.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Bleeding disorders
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
      • ·Immunosuppressants
      Before surgery
      • ·Discuss stopping ≥2 weeks before scheduled surgery.

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500–1000 mg standardized

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Herb
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      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      RCTPhytomedicine · 2011

      Olive leaf extract for hypertension

      Susalit E, et al.

      8-week RCT of 1000 mg/d olive leaf extract vs captopril.

      Key findings

      Comparable BP reduction with improvements in lipid profile.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — Reduces BP in pre-hypertensives

      Live PubMed search

      Live results for "Olive Leaf Extract Reduces BP in pre-hypertensives" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "Reduces BP in pre-hypertensives". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — randomized controlled trial

      Live PubMed search

      Live results for "Olive Leaf Extract randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — meta-analysis

      Live PubMed search

      Live results for "Olive Leaf Extract meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — pharmacokinetics

      Live PubMed search

      Live results for "Olive Leaf Extract pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — safety adverse events

      Live PubMed search

      Live results for "Olive Leaf Extract safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — dose response

      Live PubMed search

      Live results for "Olive Leaf Extract dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Olive Leaf Extract — clinical evidence

      Live Scholar search

      Cross-database citation index for Olive Leaf Extract as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.