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evidence · mechanism · dose
Supplements/Herb

Centella Triterpene Fraction

Standardized madecassoside/asiaticoside for skin and venous health.

Skin, Hair & NailsCardiovascular Health

Overview

Standardized madecassoside/asiaticoside for skin and venous health.

Natural sources
    Common forms

      Mechanism of action

      Triterpenes stimulate type I collagen.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves scar healing

        Moderate evidence

        Potential side effects

        Common
        • · Skin irritation
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid with these conditions
            • ·Bleeding disorders
            Avoid / monitor with these medications
            • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
            Before surgery
            • ·Discuss stopping ≥2 weeks before scheduled surgery.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            60–120 mg standardized

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Centella Tri…
            Amazon
            Wide selection · fast shipping
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            iHerb
            Global delivery · curated brands
            Herb
            Centella Tri…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTAngiology · 2001

            Centella for diabetic microangiopathy

            Cesarone MR, et al.

            50 patients with diabetic microangiopathy

            Key findings

            Improved venous tone and edema.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella Triterpene Fraction — Improves scar healing

            Live PubMed search

            Live results for "Centella Triterpene Fraction Improves scar healing" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Centella Triterpene Fraction and "Improves scar healing". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella Triterpene Fraction — randomized controlled trial

            Live PubMed search

            Live results for "Centella Triterpene Fraction randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Centella Triterpene Fraction and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella Triterpene Fraction — meta-analysis

            Live PubMed search

            Live results for "Centella Triterpene Fraction meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Centella Triterpene Fraction and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella Triterpene Fraction — pharmacokinetics

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella Triterpene Fraction — safety adverse events

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            Live results for "Centella Triterpene Fraction safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella Triterpene Fraction — dose response

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            Live results for "Centella Triterpene Fraction dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Centella Triterpene Fraction and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Centella Triterpene Fraction — clinical evidence

            Live Scholar search

            Cross-database citation index for Centella Triterpene Fraction as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.