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evidence · mechanism · dose
Supplements/Herb

Centella Triterpene Fraction

Standardized madecassoside/asiaticoside for skin and venous health.

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Skin, Hair & NailsCardiovascular Health

Overview

Standardized madecassoside/asiaticoside for skin and venous health.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Triterpenes stimulate type I collagen.

Pathways
  • · Triterpenes stimulate type I collagen

Effects on the body

Supports
scar healing

Organ system effects

Skin

Centella Triterpene Fraction supports collagen synthesis, antioxidant defense, or barrier function in skin and integumentary tissues.

Cardiovascular

Centella Triterpene Fraction supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.

Evidence-based benefits

Improves scar healing

Moderate evidence

Potential side effects

Common
  • · Skin irritation
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Centella Triterpene Fraction use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Bleeding disorders
      Avoid / monitor with these medications
      • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
      Before surgery
      • ·Discuss stopping ≥2 weeks before scheduled surgery.

      Supplement interactions

      Pairs well with
      • Collagen peptides
        Provides amino acid substrate for connective tissue synthesis.
      • Vitamin C
        Required cofactor for collagen hydroxylation.
      • Omega-3
        Anti-inflammatory cardiovascular synergy.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      60–120 mg standardized
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Buy on AmazonCode supplementsch-20 auto-applied
      Scientific evidence8Show studies
      RCTAngiology · 2001

      Centella for diabetic microangiopathy

      Cesarone MR, et al.

      50 patients with diabetic microangiopathy

      Key findings

      Improved venous tone and edema.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella Triterpene Fraction — Improves scar healing

      Live PubMed search

      Live results for "Centella Triterpene Fraction Improves scar healing" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella Triterpene Fraction and "Improves scar healing". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella Triterpene Fraction — randomized controlled trial

      Live PubMed search

      Live results for "Centella Triterpene Fraction randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella Triterpene Fraction and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella Triterpene Fraction — meta-analysis

      Live PubMed search

      Live results for "Centella Triterpene Fraction meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella Triterpene Fraction and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella Triterpene Fraction — pharmacokinetics

      Live PubMed search

      Live results for "Centella Triterpene Fraction pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella Triterpene Fraction and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella Triterpene Fraction — safety adverse events

      Live PubMed search

      Live results for "Centella Triterpene Fraction safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella Triterpene Fraction and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella Triterpene Fraction — dose response

      Live PubMed search

      Live results for "Centella Triterpene Fraction dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella Triterpene Fraction and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Centella Triterpene Fraction — clinical evidence

      Live Scholar search

      Cross-database citation index for Centella Triterpene Fraction as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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