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evidence · mechanism · dose
Supplements/Herb

Olive Leaf (Standardized Oleuropein)

High-oleuropein extract.

Cardiovascular HealthImmune Function

Overview

High-oleuropein extract.

Natural sources
    Common forms

      Mechanism of action

      Oleuropein has antiviral and ACE-inhibitory effects.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Antiviral and BP lowering

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid with these conditions
            • ·Bleeding disorders
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
            • ·Immunosuppressants
            Before surgery
            • ·Discuss stopping ≥2 weeks before scheduled surgery.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500 mg standardized

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Olive Leaf (…
            Amazon
            Wide selection · fast shipping
            Herb
            Olive Leaf (…
            iHerb
            Global delivery · curated brands
            Herb
            Olive Leaf (…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            In vitroPhytomedicine · 1996

            Oleuropein ACE inhibition

            Hansen K, et al.

            Enzymatic assay

            Key findings

            Inhibited ACE activity.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf (Standardized Oleuropein) — Antiviral and BP lowering

            Live PubMed search

            Live results for "Olive Leaf (Standardized Oleuropein) Antiviral and BP lowering" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "Antiviral and BP lowering". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf (Standardized Oleuropein) — randomized controlled trial

            Live PubMed search

            Live results for "Olive Leaf (Standardized Oleuropein) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf (Standardized Oleuropein) — meta-analysis

            Live PubMed search

            Live results for "Olive Leaf (Standardized Oleuropein) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf (Standardized Oleuropein) — pharmacokinetics

            Live PubMed search

            Live results for "Olive Leaf (Standardized Oleuropein) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf (Standardized Oleuropein) — safety adverse events

            Live PubMed search

            Live results for "Olive Leaf (Standardized Oleuropein) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf (Standardized Oleuropein) — dose response

            Live PubMed search

            Live results for "Olive Leaf (Standardized Oleuropein) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Olive Leaf (Standardized Oleuropein) — clinical evidence

            Live Scholar search

            Cross-database citation index for Olive Leaf (Standardized Oleuropein) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.