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evidence · mechanism · dose
Supplements/Herb

Olive Leaf (Standardized Oleuropein)

High-oleuropein extract.

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Cardiovascular HealthImmune Function

Overview

High-oleuropein extract.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Oleuropein has antiviral and ACE-inhibitory effects.

Pathways
  • · Oleuropein has antiviral
  • · ACE-inhibitory effects

Effects on the body

Supports
Antiviral and BP lowering

Organ system effects

Cardiovascular

Olive Leaf (Standardized Oleuropein) supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.

Immune System

Olive Leaf (Standardized Oleuropein) modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Evidence-based benefits

Antiviral and BP lowering

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Olive Leaf (Standardized Oleuropein) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Bleeding disorders
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
      • ·Immunosuppressants
      Before surgery
      • ·Discuss stopping ≥2 weeks before scheduled surgery.

      Supplement interactions

      Pairs well with
      • Omega-3
        Anti-inflammatory cardiovascular synergy.
      • CoQ10
        Supports mitochondrial energetics in cardiac tissue.
      • Vitamin D3 + K2
        Foundational immune modulation.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500 mg standardized
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

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      Scientific evidence8Show studies
      In vitroPhytomedicine · 1996

      Oleuropein ACE inhibition

      Hansen K, et al.

      Enzymatic assay

      Key findings

      Inhibited ACE activity.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf (Standardized Oleuropein) — Antiviral and BP lowering

      Live PubMed search

      Live results for "Olive Leaf (Standardized Oleuropein) Antiviral and BP lowering" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "Antiviral and BP lowering". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf (Standardized Oleuropein) — randomized controlled trial

      Live PubMed search

      Live results for "Olive Leaf (Standardized Oleuropein) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf (Standardized Oleuropein) — meta-analysis

      Live PubMed search

      Live results for "Olive Leaf (Standardized Oleuropein) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf (Standardized Oleuropein) — pharmacokinetics

      Live PubMed search

      Live results for "Olive Leaf (Standardized Oleuropein) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf (Standardized Oleuropein) — safety adverse events

      Live PubMed search

      Live results for "Olive Leaf (Standardized Oleuropein) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf (Standardized Oleuropein) — dose response

      Live PubMed search

      Live results for "Olive Leaf (Standardized Oleuropein) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf (Standardized Oleuropein) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Olive Leaf (Standardized Oleuropein) — clinical evidence

      Live Scholar search

      Cross-database citation index for Olive Leaf (Standardized Oleuropein) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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