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evidence · mechanism · dose
Supplements/Herb

Aged Garlic Extract (Kyolic)

Standardized aged garlic — modest BP and cholesterol benefits.

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Blood PressureCholesterolCardiovascular Health (alias)Immune Function

Overview

Standardized aged garlic — modest BP and cholesterol benefits.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

S-allyl cysteine modulates eNOS, ACE, and platelet aggregation.

Pathways
  • · S-allyl cysteine modulates eNOS, ACE
  • · and platelet aggregation

Effects on the body

Decreases
SBP ~7 mmHg in HTN

Organ system effects

Immune System

Aged Garlic Extract (Kyolic) modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Evidence-based benefits

Lowers SBP ~7 mmHg in HTN

Moderate evidence

Potential side effects

Common
  • · Garlic breath
Rare
    Serious

      Drug interactions

      Anticoagulants
      Antiplatelet effect.
      moderate

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with
      • Vitamin D3 + K2
        Foundational immune modulation.
      • Zinc
        Required cofactor for innate and adaptive immune function.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      600–1200 mg aged garlic extract
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Optional

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

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      Scientific evidence8Show studies
      RCTJ Nutr · 2009

      Aged garlic extract and atherosclerosis progression

      Budoff MJ, et al.

      1-year RCT of AGE on coronary calcium progression.

      Key findings

      Slowed coronary calcium progression vs placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — Lowers SBP ~7 mmHg in HTN

      Live PubMed search

      Live results for "Aged Garlic Extract (Kyolic) Lowers SBP ~7 mmHg in HTN" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "Lowers SBP ~7 mmHg in HTN". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — randomized controlled trial

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      Live results for "Aged Garlic Extract (Kyolic) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

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      Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — meta-analysis

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      Live results for "Aged Garlic Extract (Kyolic) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

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      Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — pharmacokinetics

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      Live results for "Aged Garlic Extract (Kyolic) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

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      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — safety adverse events

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      Live results for "Aged Garlic Extract (Kyolic) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

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      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — dose response

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      Live results for "Aged Garlic Extract (Kyolic) dose response" across the PubMed/MEDLINE peer-reviewed index.

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      Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Aged Garlic Extract (Kyolic) — clinical evidence

      Live Scholar search

      Cross-database citation index for Aged Garlic Extract (Kyolic) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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