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evidence · mechanism · dose
Supplements/Herb

Aged Garlic Extract (Kyolic)

Standardized aged garlic — modest BP and cholesterol benefits.

Blood PressureCholesterolCardiovascular Health (alias)Immune Function

Overview

Standardized aged garlic — modest BP and cholesterol benefits.

Natural sources
    Common forms

      Mechanism of action

      S-allyl cysteine modulates eNOS, ACE, and platelet aggregation.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers SBP ~7 mmHg in HTN

        Moderate evidence

        Potential side effects

        Common
        • · Garlic breath
        Rare
          Serious

            Drug interactions

            Anticoagulants
            Antiplatelet effect.
            moderate

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid with these conditions
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Immunosuppressants

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            600–1200 mg aged garlic extract
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Aged Garlic …
            Amazon
            Wide selection · fast shipping
            Herb
            Aged Garlic …
            iHerb
            Global delivery · curated brands
            Herb
            Aged Garlic …
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJ Nutr · 2009

            Aged garlic extract and atherosclerosis progression

            Budoff MJ, et al.

            1-year RCT of AGE on coronary calcium progression.

            Key findings

            Slowed coronary calcium progression vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — Lowers SBP ~7 mmHg in HTN

            Live PubMed search

            Live results for "Aged Garlic Extract (Kyolic) Lowers SBP ~7 mmHg in HTN" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "Lowers SBP ~7 mmHg in HTN". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — randomized controlled trial

            Live PubMed search

            Live results for "Aged Garlic Extract (Kyolic) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — meta-analysis

            Live PubMed search

            Live results for "Aged Garlic Extract (Kyolic) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — pharmacokinetics

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            Live results for "Aged Garlic Extract (Kyolic) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — safety adverse events

            Live PubMed search

            Live results for "Aged Garlic Extract (Kyolic) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — dose response

            Live PubMed search

            Live results for "Aged Garlic Extract (Kyolic) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Aged Garlic Extract (Kyolic) — clinical evidence

            Live Scholar search

            Cross-database citation index for Aged Garlic Extract (Kyolic) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.