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Supplements/Compound

Type III Collagen

Skin and vascular collagen.

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Overview

Skin and vascular collagen.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Component of skin, blood vessels, organs.

Pathways
  • · Component of skin, blood vessels, organs

Effects on the body

Supports
Skin support

Organ system effects

Skin

Type III Collagen supports collagen synthesis, antioxidant defense, or barrier function in skin and integumentary tissues.

Cardiovascular

Type III Collagen supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.

Evidence-based benefits

Skin support

Moderate evidence

Potential side effects

Common
  • · Well tolerated
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Type III Collagen use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Collagen peptides
        Provides amino acid substrate for connective tissue synthesis.
      • Vitamin C
        Required cofactor for collagen hydroxylation.
      • Omega-3
        Anti-inflammatory cardiovascular synergy.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      2.5–10 g
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      Systematic reviewJ Drugs Dermatol · 2019

      Collagen peptides for skin

      Choi FD, et al.

      Mechanistic review

      Key findings

      Improved skin elasticity and hydration.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Type III Collagen — Skin support

      Live PubMed search

      Live results for "Type III Collagen Skin support" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Type III Collagen and "Skin support". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Type III Collagen — randomized controlled trial

      Live PubMed search

      Live results for "Type III Collagen randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Type III Collagen and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Type III Collagen — meta-analysis

      Live PubMed search

      Live results for "Type III Collagen meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Type III Collagen and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Type III Collagen — pharmacokinetics

      Live PubMed search

      Live results for "Type III Collagen pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Type III Collagen and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Type III Collagen — safety adverse events

      Live PubMed search

      Live results for "Type III Collagen safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Type III Collagen and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Type III Collagen — dose response

      Live PubMed search

      Live results for "Type III Collagen dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Type III Collagen and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Type III Collagen — clinical evidence

      Live Scholar search

      Cross-database citation index for Type III Collagen as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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