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evidence · mechanism · dose
Supplements/Herb

Aged Garlic Extract (Kyolic)

Odorless aged garlic with S-allyl-cysteine for vascular health.

Cardiovascular HealthImmune Function

Overview

Odorless aged garlic with S-allyl-cysteine for vascular health.

Natural sources
    Common forms

      Forms & variants of Garlic

      Different chemical forms of Garlic behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Garlic

      Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.

      Mechanism of action

      S-allyl-cysteine inhibits ACE and reduces oxidative stress in endothelium.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers blood pressure in uncontrolled hypertension

        Strong evidence

        Slows coronary calcium progression

        Moderate evidence

        Potential side effects

        Common
        • · Mild GI upset
        Rare
          Serious

            Drug interactions

            Anticoagulants
            Mild antiplatelet effect.
            moderate

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid with these conditions
            • ·Bleeding disorders
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
            • ·Immunosuppressants
            Before surgery
            • ·Discuss stopping ≥2 weeks before scheduled surgery.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            240–960 mg AGE
            With food?
            Either

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Aged Garlic …
            Amazon
            Wide selection · fast shipping
            Herb
            Aged Garlic …
            iHerb
            Global delivery · curated brands
            Herb
            Aged Garlic …
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            RCTJ Nutr · 2009

            Aged garlic on coronary calcification

            Budoff MJ, et al.

            1-year DB-RCT in 65 statin-treated patients.

            Key findings

            AGE + B-complex slowed progression of coronary artery calcium vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — Lowers blood pressure in uncontrolled hypertension

            Live PubMed search

            Live results for "Aged Garlic Extract (Kyolic) Lowers blood pressure in uncontrolled hypertension" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "Lowers blood pressure in uncontrolled hypertension". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — Slows coronary calcium progression

            Live PubMed search

            Live results for "Aged Garlic Extract (Kyolic) Slows coronary calcium progression" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "Slows coronary calcium progression". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — randomized controlled trial

            Live PubMed search

            Live results for "Aged Garlic Extract (Kyolic) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — meta-analysis

            Live PubMed search

            Live results for "Aged Garlic Extract (Kyolic) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — pharmacokinetics

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            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — safety adverse events

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            Live results for "Aged Garlic Extract (Kyolic) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Aged Garlic Extract (Kyolic) — dose response

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            Live results for "Aged Garlic Extract (Kyolic) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Aged Garlic Extract (Kyolic) — clinical evidence

            Live Scholar search

            Cross-database citation index for Aged Garlic Extract (Kyolic) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.