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Aged Garlic Extract (Kyolic)

Odorless aged garlic with S-allyl-cysteine for vascular health.

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Cardiovascular HealthImmune Function

Overview

Odorless aged garlic with S-allyl-cysteine for vascular health.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Forms & variants of Garlic

Different chemical forms of Garlic behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Parent
Garlic

Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.

Mechanism of action

S-allyl-cysteine inhibits ACE and reduces oxidative stress in endothelium.

Pathways
  • · S-allyl-cysteine inhibits ACE
  • · reduces oxidative stress in endothelium

Effects on the body

Decreases
blood pressure in uncontrolled hypertension
Supports
Slows coronary calcium progression

Organ system effects

Cardiovascular

Aged Garlic Extract (Kyolic) supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.

Immune System

Aged Garlic Extract (Kyolic) modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Evidence-based benefits

Lowers blood pressure in uncontrolled hypertension

Strong evidence

Slows coronary calcium progression

Moderate evidence

Potential side effects

Common
  • · Mild GI upset
Rare
    Serious

      Drug interactions

      Anticoagulants
      Mild antiplatelet effect.
      moderate

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Bleeding disorders
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
      • ·Immunosuppressants
      Before surgery
      • ·Discuss stopping ≥2 weeks before scheduled surgery.

      Supplement interactions

      Pairs well with
      • Omega-3
        Anti-inflammatory cardiovascular synergy.
      • CoQ10
        Supports mitochondrial energetics in cardiac tissue.
      • Vitamin D3 + K2
        Foundational immune modulation.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      240–960 mg AGE
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

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      Scientific evidence9Show studies
      RCTJ Nutr · 2009

      Aged garlic on coronary calcification

      Budoff MJ, et al.

      1-year DB-RCT in 65 statin-treated patients.

      Key findings

      AGE + B-complex slowed progression of coronary artery calcium vs placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — Lowers blood pressure in uncontrolled hypertension

      Live PubMed search

      Live results for "Aged Garlic Extract (Kyolic) Lowers blood pressure in uncontrolled hypertension" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "Lowers blood pressure in uncontrolled hypertension". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — Slows coronary calcium progression

      Live PubMed search

      Live results for "Aged Garlic Extract (Kyolic) Slows coronary calcium progression" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "Slows coronary calcium progression". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — randomized controlled trial

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      Live results for "Aged Garlic Extract (Kyolic) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — meta-analysis

      Live PubMed search

      Live results for "Aged Garlic Extract (Kyolic) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — pharmacokinetics

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      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — safety adverse events

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      Live results for "Aged Garlic Extract (Kyolic) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

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      Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Aged Garlic Extract (Kyolic) — dose response

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      Live results for "Aged Garlic Extract (Kyolic) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Aged Garlic Extract (Kyolic) — clinical evidence

      Live Scholar search

      Cross-database citation index for Aged Garlic Extract (Kyolic) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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