Overview
Re-esterified triglyceride EPA/DHA — ~70% better absorption than ethyl ester form.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Forms & variants of Omega-3 (rTG form)
Different chemical forms of Omega-3 (rTG form) behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Concentrated EE form found in most prescription and budget fish oils — cheaper, less bioavailable.
Phospholipid-bound EPA/DHA from Antarctic krill — includes astaxanthin antioxidant.
Plant-source DHA (and some EPA) from cultivated marine algae — vegan alternative to fish oil.
Mechanism of action
Native triglyceride structure mimics dietary fish oil — efficiently hydrolyzed by pancreatic lipase.
- · Native triglyceride structure mimics dietary fish oil — efficiently hydrolyzed by pancreatic lipase
Effects on the body
Organ system effects
Omega-3 (rTG form) supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Omega-3 (rTG form) acts on central nervous system targets implicated in attention, memory, and neuroprotection.
Evidence-based benefits
Higher plasma EPA/DHA vs ethyl ester at equal dose
Strong evidencePotential side effects
- · Fishy reflux
Drug interactions
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
- Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Scientific evidence8Show studiesHide studies
Triglyceride vs ethyl-ester omega-3 absorption
Dyerberg J, et al.
2-week crossover comparing rTG and EE forms.
rTG form absorbed ~70% better than EE form.
PubMed: Omega-3 (rTG form) — Higher plasma EPA/DHA vs ethyl ester at equal dose
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PubMed: Omega-3 (rTG form) — randomized controlled trial
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PubMed: Omega-3 (rTG form) — pharmacokinetics
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PubMed: Omega-3 (rTG form) — safety adverse events
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PubMed: Omega-3 (rTG form) — dose response
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Google Scholar: Omega-3 (rTG form) — clinical evidence
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Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.