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evidence · mechanism · dose
Supplements/Fatty Acid

Omega-3 (rTG form)

Re-esterified triglyceride EPA/DHA — ~70% better absorption than ethyl ester form.

Cardiovascular HealthBrain & CognitiveChronic Inflammation

Overview

Re-esterified triglyceride EPA/DHA — ~70% better absorption than ethyl ester form.

Natural sources
    Common forms

      Forms & variants of Omega-3 (rTG form)

      Different chemical forms of Omega-3 (rTG form) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Ethyl Ester
      Omega-3 (Ethyl Ester)

      Concentrated EE form found in most prescription and budget fish oils — cheaper, less bioavailable.

      Krill (Phospholipid)
      Krill Oil

      Phospholipid-bound EPA/DHA from Antarctic krill — includes astaxanthin antioxidant.

      Algal (Vegan)
      Algal Omega-3 (DHA/EPA)

      Plant-source DHA (and some EPA) from cultivated marine algae — vegan alternative to fish oil.

      Mechanism of action

      Native triglyceride structure mimics dietary fish oil — efficiently hydrolyzed by pancreatic lipase.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Higher plasma EPA/DHA vs ethyl ester at equal dose

        Strong evidence

        Potential side effects

        Common
        • · Fishy reflux
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1–3 g combined EPA+DHA
            With food?
            With fatty meal

            Where to buy

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTProstaglandins Leukot Essent Fatty Acids · 2010

            Triglyceride vs ethyl-ester omega-3 absorption

            Dyerberg J, et al.

            2-week crossover comparing rTG and EE forms.

            Key findings

            rTG form absorbed ~70% better than EE form.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Omega-3 (rTG form) — Higher plasma EPA/DHA vs ethyl ester at equal dose

            Live PubMed search

            Live results for "Omega-3 (rTG form) Higher plasma EPA/DHA vs ethyl ester at equal dose" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Omega-3 (rTG form) and "Higher plasma EPA/DHA vs ethyl ester at equal dose". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Omega-3 (rTG form) — randomized controlled trial

            Live PubMed search

            Live results for "Omega-3 (rTG form) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Omega-3 (rTG form) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Omega-3 (rTG form) — meta-analysis

            Live PubMed search

            Live results for "Omega-3 (rTG form) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Omega-3 (rTG form) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Omega-3 (rTG form) — pharmacokinetics

            Live PubMed search

            Live results for "Omega-3 (rTG form) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Omega-3 (rTG form) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Omega-3 (rTG form) — safety adverse events

            Live PubMed search

            Live results for "Omega-3 (rTG form) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Omega-3 (rTG form) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Omega-3 (rTG form) — dose response

            Live PubMed search

            Live results for "Omega-3 (rTG form) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Omega-3 (rTG form) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Omega-3 (rTG form) — clinical evidence

            Live Scholar search

            Cross-database citation index for Omega-3 (rTG form) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.