Overview
Mitochondrial-targeted peptide for cardiolipin protection.
- Synthetic peptide manufactured to pharmaceutical or research-grade purity
- Subcutaneous injection, sublingual, or oral preparation depending on bioavailability
- Compounded by a licensed pharmacy for clinical use
- Subcutaneous injection
- Oral or sublingual lozenge
- Nasal spray
- Compounded topical
Mechanism of action
Binds cardiolipin, stabilizes mitochondrial cristae.
- · Binds cardiolipin, stabilizes mitochondrial cristae
Effects on the body
Organ system effects
SS-31 (Elamipretide) supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
SS-31 (Elamipretide) acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Evidence-based benefits
Improves mitochondrial function
Moderate evidencePotential side effects
- · Injection site reactions
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Most research peptides are not FDA-approved for human use outside investigational protocols.
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified SS-31 (Elamipretide) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.SS-31 (Elamipretide) third party tested NSF
CapsulesPre-measured SS-31 (Elamipretide) capsules — easiest for travel and consistent daily dosing without scoops or scales.SS-31 (Elamipretide) capsules
PowderBulk unflavored SS-31 (Elamipretide) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.SS-31 (Elamipretide) powder unflavored
Best sellersMost-purchased SS-31 (Elamipretide) products on Amazon — a quick way to see what's reviewed widely before you commit.SS-31 (Elamipretide) best sellerScientific evidence8Show studiesHide studies
Elamipretide in heart failure
Daubert MA, et al.
HFrEF patients
Improved LV end-systolic volume.
PubMed: SS-31 (Elamipretide) — Improves mitochondrial function
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