Overview
Fermented soy serine protease with fibrinolytic activity.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Degrades fibrin directly and activates plasminogen activators.
- · Degrades fibrin directly
- · activates plasminogen activators
Effects on the body
Organ system effects
Nattokinase supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Evidence-based benefits
Lowers blood pressure and fibrinogen
Moderate evidencePotential side effects
- · GI upset
- · Bleeding risk if combined with anticoagulants
Drug interactions
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Nattokinase — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Nattokinase third party tested NSF
CapsulesPre-measured Nattokinase capsules — easiest for travel and consistent daily dosing without scoops or scales.Nattokinase capsules
PowderBulk unflavored Nattokinase powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Nattokinase powder unflavored
Best sellersMost-purchased Nattokinase products on Amazon — a quick way to see what's reviewed widely before you commit.Nattokinase best sellerScientific evidence8Show studiesHide studies
Nattokinase for HTN
Kim JY, et al.
8-week DB-RCT in 86 HTN patients.
2000 FU/day reduced SBP/DBP vs placebo.
PubMed: Nattokinase — Lowers blood pressure and fibrinogen
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