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evidence · mechanism · dose
Supplements/Compound

Nattokinase

Fermented soy serine protease with fibrinolytic activity.

Cardiovascular Health

Overview

Fermented soy serine protease with fibrinolytic activity.

Natural sources
    Common forms

      Mechanism of action

      Degrades fibrin directly and activates plasminogen activators.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers blood pressure and fibrinogen

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious
          • · Bleeding risk if combined with anticoagulants

          Drug interactions

          Anticoagulants/Antiplatelets
          Major bleeding risk; do not combine.
          severe

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          2000 FU (≈100 mg)
          With food?
          Either

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Compound
          Nattokinase
          Amazon
          Wide selection · fast shipping
          Compound
          Nattokinase
          iHerb
          Global delivery · curated brands
          Compound
          Nattokinase
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTHypertens Res · 2008

          Nattokinase for HTN

          Kim JY, et al.

          8-week DB-RCT in 86 HTN patients.

          Key findings

          2000 FU/day reduced SBP/DBP vs placebo.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Nattokinase — Lowers blood pressure and fibrinogen

          Live PubMed search

          Live results for "Nattokinase Lowers blood pressure and fibrinogen" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Nattokinase and "Lowers blood pressure and fibrinogen". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Nattokinase — randomized controlled trial

          Live PubMed search

          Live results for "Nattokinase randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Nattokinase and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Nattokinase — meta-analysis

          Live PubMed search

          Live results for "Nattokinase meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Nattokinase and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Nattokinase — pharmacokinetics

          Live PubMed search

          Live results for "Nattokinase pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Nattokinase and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Nattokinase — safety adverse events

          Live PubMed search

          Live results for "Nattokinase safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Nattokinase and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Nattokinase — dose response

          Live PubMed search

          Live results for "Nattokinase dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Nattokinase and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Nattokinase — clinical evidence

          Live Scholar search

          Cross-database citation index for Nattokinase as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.