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evidence · mechanism · dose
Supplements/Compound

Grape Seed Extract

Vitis vinifera procyanidins.

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Overview

Vitis vinifera procyanidins.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Anti-inflammatory; collagen protection.

Pathways
  • · Anti-inflammatory
  • · collagen protection

Effects on the body

Decreases
BP

Organ system effects

Cardiovascular

Grape Seed Extract supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.

Skin

Grape Seed Extract supports collagen synthesis, antioxidant defense, or barrier function in skin and integumentary tissues.

Evidence-based benefits

Lowers BP

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Grape Seed Extract use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Omega-3
        Anti-inflammatory cardiovascular synergy.
      • CoQ10
        Supports mitochondrial energetics in cardiac tissue.
      • Collagen peptides
        Provides amino acid substrate for connective tissue synthesis.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      150–300 mg
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Buy on AmazonCode supplementsch-20 auto-applied
      Scientific evidence8Show studies
      Meta-analysisJ Am Diet Assoc · 2011

      Grape seed for BP

      Feringa HH, et al.

      9 RCTs

      Key findings

      Reduced systolic BP by 1.5 mmHg.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Grape Seed Extract — Lowers BP

      Live PubMed search

      Live results for "Grape Seed Extract Lowers BP" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Grape Seed Extract and "Lowers BP". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Grape Seed Extract — randomized controlled trial

      Live PubMed search

      Live results for "Grape Seed Extract randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Grape Seed Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Grape Seed Extract — meta-analysis

      Live PubMed search

      Live results for "Grape Seed Extract meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Grape Seed Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Grape Seed Extract — pharmacokinetics

      Live PubMed search

      Live results for "Grape Seed Extract pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Grape Seed Extract and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Grape Seed Extract — safety adverse events

      Live PubMed search

      Live results for "Grape Seed Extract safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Grape Seed Extract and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Grape Seed Extract — dose response

      Live PubMed search

      Live results for "Grape Seed Extract dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Grape Seed Extract and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Grape Seed Extract — clinical evidence

      Live Scholar search

      Cross-database citation index for Grape Seed Extract as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

      Community discussion

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