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evidence · mechanism · dose
Supplements/Herb

Horse Chestnut

Aesculus seed extract for chronic venous insufficiency.

Cardiovascular Health

Overview

Aesculus seed extract for chronic venous insufficiency.

Natural sources
    Common forms

      Mechanism of action

      Aescin reduces capillary permeability and edema.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces leg swelling

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        • · Itching
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid with these conditions
            • ·Bleeding disorders
            Avoid / monitor with these medications
            • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
            Before surgery
            • ·Discuss stopping ≥2 weeks before scheduled surgery.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300 mg standardized (50 mg aescin) BID

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Horse Chestnut
            Amazon
            Wide selection · fast shipping
            Herb
            Horse Chestnut
            iHerb
            Global delivery · curated brands
            Herb
            Horse Chestnut
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Meta-analysisCochrane · 2012

            Horse chestnut for CVI

            Pittler MH, Ernst E

            17 RCTs

            Key findings

            Reduced leg pain and edema vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Horse Chestnut — Reduces leg swelling

            Live PubMed search

            Live results for "Horse Chestnut Reduces leg swelling" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Horse Chestnut and "Reduces leg swelling". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Horse Chestnut — randomized controlled trial

            Live PubMed search

            Live results for "Horse Chestnut randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Horse Chestnut and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Horse Chestnut — meta-analysis

            Live PubMed search

            Live results for "Horse Chestnut meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Horse Chestnut and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Horse Chestnut — pharmacokinetics

            Live PubMed search

            Live results for "Horse Chestnut pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Horse Chestnut and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Horse Chestnut — safety adverse events

            Live PubMed search

            Live results for "Horse Chestnut safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Horse Chestnut and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Horse Chestnut — dose response

            Live PubMed search

            Live results for "Horse Chestnut dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Horse Chestnut and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Horse Chestnut — clinical evidence

            Live Scholar search

            Cross-database citation index for Horse Chestnut as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.