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Supplements/Compound

Cuban Policosanol

Sugar-cane–derived lipid-lowering long-chain alcohols.

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Overview

Sugar-cane–derived lipid-lowering long-chain alcohols.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Forms & variants of Policosanol

Different chemical forms of Policosanol behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Mechanism of action

Inhibits HMG-CoA reductase activation and modulates platelet aggregation.

Pathways
  • · Inhibits HMG-CoA reductase activation
  • · modulates platelet aggregation

Effects on the body

Decreases
LDL in Cuban trials (not replicated by non-Cuban researchers)

Organ system effects

Cardiovascular

Cuban Policosanol supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.

Evidence-based benefits

Lowers LDL in Cuban trials (not replicated by non-Cuban researchers)

Limited evidence

Potential side effects

Common
  • · Headache
Rare
    Serious

      Drug interactions

      Antiplatelets
      Additive bleeding risk.
      moderate

      Supplement interactions

      Pairs well with
      • Omega-3
        Anti-inflammatory cardiovascular synergy.
      • CoQ10
        Supports mitochondrial energetics in cardiac tissue.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      10–20 mg
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Evening

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTJAMA · 2006

      Policosanol vs placebo in dyslipidemia

      Berthold HK, et al.

      12-week DB-RCT in 143 Caucasians.

      Key findings

      No effect on LDL, HDL, or triglycerides at 80 mg/day.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Cuban Policosanol — Lowers LDL in Cuban trials

      Live PubMed search

      Live results for "Cuban Policosanol Lowers LDL in Cuban trials" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Cuban Policosanol and "Lowers LDL in Cuban trials". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Cuban Policosanol — randomized controlled trial

      Live PubMed search

      Live results for "Cuban Policosanol randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Cuban Policosanol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Cuban Policosanol — meta-analysis

      Live PubMed search

      Live results for "Cuban Policosanol meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Cuban Policosanol and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Cuban Policosanol — pharmacokinetics

      Live PubMed search

      Live results for "Cuban Policosanol pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Cuban Policosanol and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Cuban Policosanol — safety adverse events

      Live PubMed search

      Live results for "Cuban Policosanol safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Cuban Policosanol and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Cuban Policosanol — dose response

      Live PubMed search

      Live results for "Cuban Policosanol dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Cuban Policosanol and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Cuban Policosanol — clinical evidence

      Live Scholar search

      Cross-database citation index for Cuban Policosanol as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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