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evidence · mechanism · dose
Supplements/Compound

Cuban Policosanol

Sugar-cane–derived lipid-lowering long-chain alcohols.

Cardiovascular Health

Overview

Sugar-cane–derived lipid-lowering long-chain alcohols.

Natural sources
    Common forms

      Forms & variants of Policosanol

      Different chemical forms of Policosanol behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Policosanol

      Long-chain alcohols from sugarcane wax marketed for cholesterol; Cuban studies positive but unreplicated.

      Parent
      Policosanol

      Sugar cane alcohols — mixed evidence for lipid lowering (Cuban trials positive, others negative).

      Mechanism of action

      Inhibits HMG-CoA reductase activation and modulates platelet aggregation.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers LDL in Cuban trials (not replicated by non-Cuban researchers)

        Limited evidence

        Potential side effects

        Common
        • · Headache
        Rare
          Serious

            Drug interactions

            Antiplatelets
            Additive bleeding risk.
            moderate

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            10–20 mg
            With food?
            Evening

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Cuban Polico…
            Amazon
            Wide selection · fast shipping
            Compound
            Cuban Polico…
            iHerb
            Global delivery · curated brands
            Compound
            Cuban Polico…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJAMA · 2006

            Policosanol vs placebo in dyslipidemia

            Berthold HK, et al.

            12-week DB-RCT in 143 Caucasians.

            Key findings

            No effect on LDL, HDL, or triglycerides at 80 mg/day.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cuban Policosanol — Lowers LDL in Cuban trials

            Live PubMed search

            Live results for "Cuban Policosanol Lowers LDL in Cuban trials" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cuban Policosanol and "Lowers LDL in Cuban trials". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cuban Policosanol — randomized controlled trial

            Live PubMed search

            Live results for "Cuban Policosanol randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cuban Policosanol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cuban Policosanol — meta-analysis

            Live PubMed search

            Live results for "Cuban Policosanol meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cuban Policosanol and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cuban Policosanol — pharmacokinetics

            Live PubMed search

            Live results for "Cuban Policosanol pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cuban Policosanol and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cuban Policosanol — safety adverse events

            Live PubMed search

            Live results for "Cuban Policosanol safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cuban Policosanol and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cuban Policosanol — dose response

            Live PubMed search

            Live results for "Cuban Policosanol dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cuban Policosanol and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Cuban Policosanol — clinical evidence

            Live Scholar search

            Cross-database citation index for Cuban Policosanol as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.