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evidence · mechanism · dose
Supplements/Fatty Acid

Squalene

Olive oil/shark liver lipid antioxidant.

Skin, Hair & NailsCardiovascular Health

Overview

Olive oil/shark liver lipid antioxidant.

Natural sources
    Common forms

      Mechanism of action

      Acts as singlet oxygen quencher; precursor to cholesterol.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Skin moisturization

        Moderate evidence

        Potential side effects

        Common
        • · Acne if comedogenic
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–1000 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Fatty Acid
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            Amazon
            Wide selection · fast shipping
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            iHerb
            Global delivery · curated brands
            Fatty Acid
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewAdv Drug Deliv Rev · 2009

            Squalene cardiovascular review

            Reddy LH, Couvreur P

            Pharmacological review

            Key findings

            Cholesterol-lowering and antioxidant activity.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Squalene — Skin moisturization

            Live PubMed search

            Live results for "Squalene Skin moisturization" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Squalene and "Skin moisturization". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Squalene — randomized controlled trial

            Live PubMed search

            Live results for "Squalene randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Squalene and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Squalene — meta-analysis

            Live PubMed search

            Live results for "Squalene meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Squalene and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Squalene — pharmacokinetics

            Live PubMed search

            Live results for "Squalene pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Squalene and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Squalene — safety adverse events

            Live PubMed search

            Live results for "Squalene safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Squalene and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Squalene — dose response

            Live PubMed search

            Live results for "Squalene dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Squalene and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Squalene — clinical evidence

            Live Scholar search

            Cross-database citation index for Squalene as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.