Overview
Olive oil/shark liver lipid antioxidant.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Acts as singlet oxygen quencher; precursor to cholesterol.
- · Acts as singlet oxygen quencher
- · precursor to cholesterol
Effects on the body
Organ system effects
Squalene supports collagen synthesis, antioxidant defense, or barrier function in skin and integumentary tissues.
Squalene supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Evidence-based benefits
Skin moisturization
Moderate evidencePotential side effects
- · Acne if comedogenic
Drug interactions
Supplement interactions
- Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
- Vitamin CRequired cofactor for collagen hydroxylation.
- Omega-3Anti-inflammatory cardiovascular synergy.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Squalene — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Squalene third party tested NSF
CapsulesPre-measured Squalene capsules — easiest for travel and consistent daily dosing without scoops or scales.Squalene capsules
PowderBulk unflavored Squalene powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Squalene powder unflavored
Best sellersMost-purchased Squalene products on Amazon — a quick way to see what's reviewed widely before you commit.Squalene best sellerScientific evidence8Show studiesHide studies
Squalene cardiovascular review
Reddy LH, Couvreur P
Pharmacological review
Cholesterol-lowering and antioxidant activity.
PubMed: Squalene — Skin moisturization
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PubMed: Squalene — randomized controlled trial
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PubMed: Squalene — meta-analysis
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PubMed: Squalene — pharmacokinetics
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PubMed: Squalene — safety adverse events
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PubMed: Squalene — dose response
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Google Scholar: Squalene — clinical evidence
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Cross-database citation index for Squalene as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.