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evidence · mechanism · dose
Supplements/Mineral

Magnesium Sulfate (IV)

Reference IV form used in eclampsia and acute asthma.

Cardiovascular HealthGeneral Wellness

Overview

Reference IV form used in eclampsia and acute asthma.

Natural sources
    Common forms

      Forms & variants of Magnesium

      Different chemical forms of Magnesium behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Magnesium

      Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.

      Glycinate
      Magnesium Glycinate

      Chelated magnesium bound to glycine — best-tolerated form for sleep, calm, and muscle relaxation.

      Citrate
      Magnesium Citrate

      Highly bioavailable magnesium with a mild osmotic laxative effect — useful for constipation and repletion.

      Malate
      Magnesium Malate

      Magnesium + malic acid — favored for daytime energy and fibromyalgia-related fatigue.

      L-Threonate
      Magnesium L-Threonate

      Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.

      Taurate
      Magnesium Taurate

      Magnesium + taurine — gentle on the gut with cardiovascular and glycemic synergies.

      Oxide
      Magnesium Oxide

      Cheapest magnesium salt — poor absorption (~4%) but useful as a laxative or antacid.

      Chloride
      Magnesium Chloride

      Topical and oral magnesium with good absorption — commonly used in 'magnesium oil' sprays.

      Orotate
      Magnesium Orotate

      Magnesium + orotic acid — studied specifically in heart failure and athletic populations.

      Acetyl-taurate
      Magnesium Acetyl-Taurate

      Brain-penetrant Mg form combined with taurate for mood.

      Mechanism of action

      Calcium channel modulator and bronchodilator at high serum levels.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Prevents eclamptic seizures

        Strong evidence

        Potential side effects

        Common
        • · Flushing
        • · Warmth
        Rare
        • · Respiratory depression
        Serious
        • · Requires medical setting

        Drug interactions

        No notable interactions reported.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        Rx only

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Mineral
        Magnesium Su…
        Amazon
        Wide selection · fast shipping
        Mineral
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        iHerb
        Global delivery · curated brands
        Mineral
        Magnesium Su…
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        RCTLancet · 2002

        MagPIE trial of magsulf in pre-eclampsia

        Altman D, et al.

        10,141 women with pre-eclampsia.

        Key findings

        MgSO4 halved the risk of eclamptic seizures.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Magnesium Sulfate (IV) — Prevents eclamptic seizures

        Live PubMed search

        Live results for "Magnesium Sulfate (IV) Prevents eclamptic seizures" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Magnesium Sulfate (IV) and "Prevents eclamptic seizures". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Magnesium Sulfate (IV) — randomized controlled trial

        Live PubMed search

        Live results for "Magnesium Sulfate (IV) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Magnesium Sulfate (IV) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Magnesium Sulfate (IV) — meta-analysis

        Live PubMed search

        Live results for "Magnesium Sulfate (IV) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Magnesium Sulfate (IV) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Magnesium Sulfate (IV) — pharmacokinetics

        Live PubMed search

        Live results for "Magnesium Sulfate (IV) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Magnesium Sulfate (IV) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Magnesium Sulfate (IV) — safety adverse events

        Live PubMed search

        Live results for "Magnesium Sulfate (IV) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Magnesium Sulfate (IV) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Magnesium Sulfate (IV) — dose response

        Live PubMed search

        Live results for "Magnesium Sulfate (IV) dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Magnesium Sulfate (IV) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Magnesium Sulfate (IV) — clinical evidence

        Live Scholar search

        Cross-database citation index for Magnesium Sulfate (IV) as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.