SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Mineral

Magnesium L-Threonate

Mg form designed for brain penetration; studied for cognition and sleep.

Brain & CognitiveSleep & Recovery

Overview

Patented magnesium chelate (Magtein) shown in animals to raise brain Mg.

Natural sources
  • Synthesized
Common forms
  • Magtein

Mechanism of action

Crosses BBB more effectively than other Mg forms; raises synaptic Mg.

Pathways
  • · NMDA receptor modulation

Effects on the body

Supports
Synaptic plasticity
Supports
Sleep quality

Organ system effects

Brain & CNS

Improves cognition in older adults (small RCT).

Evidence-based benefits

Improves cognitive performance in older adults

Limited evidence

Potential side effects

Common
  • · Headache (rare)
Rare
    Serious

      Drug interactions

      No notable interactions reported.

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid / monitor with these medications
      • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      1.5–2 g (= 144 mg elemental Mg) before bed

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Mineral
      Magnesium L-…
      Amazon
      Wide selection · fast shipping
      Mineral
      Magnesium L-…
      iHerb
      Global delivery · curated brands
      Mineral
      Magnesium L-…
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      RCTJ Alzheimers Dis · 2016

      Magnesium-L-threonate on cognitive impairment in older adults

      Liu G, et al.

      12-week RCT of MgT on cognition.

      Key findings

      Improved executive function, working memory, and episodic memory.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnesium L-Threonate — Improves cognitive performance in older adults

      Live PubMed search

      Live results for "Magnesium L-Threonate Improves cognitive performance in older adults" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnesium L-Threonate and "Improves cognitive performance in older adults". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnesium L-Threonate — randomized controlled trial

      Live PubMed search

      Live results for "Magnesium L-Threonate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnesium L-Threonate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnesium L-Threonate — meta-analysis

      Live PubMed search

      Live results for "Magnesium L-Threonate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnesium L-Threonate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnesium L-Threonate — pharmacokinetics

      Live PubMed search

      Live results for "Magnesium L-Threonate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnesium L-Threonate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnesium L-Threonate — safety adverse events

      Live PubMed search

      Live results for "Magnesium L-Threonate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnesium L-Threonate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnesium L-Threonate — dose response

      Live PubMed search

      Live results for "Magnesium L-Threonate dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnesium L-Threonate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Magnesium L-Threonate — clinical evidence

      Live Scholar search

      Cross-database citation index for Magnesium L-Threonate as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.