Overview
Patented magnesium chelate (Magtein) shown in animals to raise brain Mg.
- Synthesized
- Magtein
Mechanism of action
Crosses BBB more effectively than other Mg forms; raises synaptic Mg.
- · NMDA receptor modulation
Effects on the body
Organ system effects
Improves cognition in older adults (small RCT).
Evidence-based benefits
Improves cognitive performance in older adults
Limited evidencePotential side effects
- · Headache (rare)
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)
Supplement interactions
- Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
- Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
- Magnesium glycinateComplementary GABAergic calming and improved sleep architecture.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Magnesium L-Threonate — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Magnesium L-Threonate third party tested NSF
CapsulesPre-measured Magnesium L-Threonate capsules — easiest for travel and consistent daily dosing without scoops or scales.Magnesium L-Threonate capsules
PowderBulk unflavored Magnesium L-Threonate powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Magnesium L-Threonate powder unflavored
Best sellersMost-purchased Magnesium L-Threonate products on Amazon — a quick way to see what's reviewed widely before you commit.Magnesium L-Threonate best sellerScientific evidence8Show studiesHide studies
Magnesium-L-threonate on cognitive impairment in older adults
Liu G, et al.
12-week RCT of MgT on cognition.
Improved executive function, working memory, and episodic memory.
PubMed: Magnesium L-Threonate — Improves cognitive performance in older adults
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