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evidence · mechanism · dose
Supplements/Mineral

Magnesium Acetyl-Taurate

Brain-penetrant Mg form combined with taurate for mood.

Mood & AnxietyBrain & CognitiveGeneral Wellness

Overview

Brain-penetrant Mg form combined with taurate for mood.

Natural sources
    Common forms

      Forms & variants of Magnesium

      Different chemical forms of Magnesium behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Magnesium

      Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.

      Glycinate
      Magnesium Glycinate

      Chelated magnesium bound to glycine — best-tolerated form for sleep, calm, and muscle relaxation.

      Citrate
      Magnesium Citrate

      Highly bioavailable magnesium with a mild osmotic laxative effect — useful for constipation and repletion.

      Malate
      Magnesium Malate

      Magnesium + malic acid — favored for daytime energy and fibromyalgia-related fatigue.

      L-Threonate
      Magnesium L-Threonate

      Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.

      Taurate
      Magnesium Taurate

      Magnesium + taurine — gentle on the gut with cardiovascular and glycemic synergies.

      Oxide
      Magnesium Oxide

      Cheapest magnesium salt — poor absorption (~4%) but useful as a laxative or antacid.

      Chloride
      Magnesium Chloride

      Topical and oral magnesium with good absorption — commonly used in 'magnesium oil' sprays.

      Orotate
      Magnesium Orotate

      Magnesium + orotic acid — studied specifically in heart failure and athletic populations.

      Sulfate (IV)
      Magnesium Sulfate (IV)

      Reference IV form used in eclampsia and acute asthma.

      Mechanism of action

      Crosses BBB to raise CSF magnesium; supports NMDA modulation.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces depression scores in T2DM (small RCT)

        Limited evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            200–400 mg elemental
            With food?
            Either

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPLoS ONE · 2017

            Magnesium for depression

            Tarleton EK, et al.

            6-week open RCT in 126 mild-moderate depression patients.

            Key findings

            248 mg/day Mg improved PHQ-9 score significantly.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Acetyl-Taurate — Reduces depression scores in T2DM

            Live PubMed search

            Live results for "Magnesium Acetyl-Taurate Reduces depression scores in T2DM" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Acetyl-Taurate and "Reduces depression scores in T2DM". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Acetyl-Taurate — randomized controlled trial

            Live PubMed search

            Live results for "Magnesium Acetyl-Taurate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Acetyl-Taurate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Acetyl-Taurate — meta-analysis

            Live PubMed search

            Live results for "Magnesium Acetyl-Taurate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Acetyl-Taurate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Acetyl-Taurate — pharmacokinetics

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            Live results for "Magnesium Acetyl-Taurate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Acetyl-Taurate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Acetyl-Taurate — safety adverse events

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            Live results for "Magnesium Acetyl-Taurate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Acetyl-Taurate — dose response

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            Live results for "Magnesium Acetyl-Taurate dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Acetyl-Taurate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Magnesium Acetyl-Taurate — clinical evidence

            Live Scholar search

            Cross-database citation index for Magnesium Acetyl-Taurate as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.