Overview
Bisglycinate chelate form of magnesium — gentle, well-absorbed, ideal for sleep.
- Chelated magnesium
- Magnesium bisglycinate
Mechanism of action
Glycine chelation improves absorption and provides additional calming glycine.
- · NMDA modulation (glycine)
Effects on the body
Organ system effects
Sleep-supportive Mg form.
Evidence-based benefits
Improves sleep & reduces cramps
Moderate evidencePotential side effects
- · Magnesium Glycinate is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)
Supplement interactions
- Magnesium glycinateComplementary GABAergic calming and improved sleep architecture.
- L-theanineReduces sleep latency without sedation.
- AshwagandhaAdaptogenic HPA-axis modulation.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Magnesium Glycinate — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Magnesium Glycinate third party tested NSF
CapsulesPre-measured Magnesium Glycinate capsules — easiest for travel and consistent daily dosing without scoops or scales.Magnesium Glycinate capsules
PowderBulk unflavored Magnesium Glycinate powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Magnesium Glycinate powder unflavored
Best sellersMost-purchased Magnesium Glycinate products on Amazon — a quick way to see what's reviewed widely before you commit.Magnesium Glycinate best sellerScientific evidence8Show studiesHide studies
Magnesium glycinate and sleep quality in older adults
Abbasi B, et al.
8-week RCT of magnesium in elderly insomniacs.
Improved insomnia severity, sleep efficiency, and serum cortisol.
PubMed: Magnesium Glycinate — Improves sleep & reduces cramps
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