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evidence · mechanism · dose
Supplements/Compound

TMG (Betaine Anhydrous)

Methyl donor for homocysteine reduction.

Cardiovascular Health

Overview

Methyl donor for homocysteine reduction.

Natural sources
    Common forms

      Mechanism of action

      Methylates homocysteine to methionine.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers homocysteine

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            3–6 g

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            TMG (Betaine…
            Amazon
            Wide selection · fast shipping
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            iHerb
            Global delivery · curated brands
            Compound
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJ Int Soc Sports Nutr · 2013

            Betaine and power output

            Cholewa JM, et al.

            23 trained men

            Key findings

            Improved cycle sprint power.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: TMG (Betaine Anhydrous) — Lowers homocysteine

            Live PubMed search

            Live results for "TMG (Betaine Anhydrous) Lowers homocysteine" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching TMG (Betaine Anhydrous) and "Lowers homocysteine". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: TMG (Betaine Anhydrous) — randomized controlled trial

            Live PubMed search

            Live results for "TMG (Betaine Anhydrous) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching TMG (Betaine Anhydrous) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: TMG (Betaine Anhydrous) — meta-analysis

            Live PubMed search

            Live results for "TMG (Betaine Anhydrous) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching TMG (Betaine Anhydrous) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: TMG (Betaine Anhydrous) — pharmacokinetics

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            Live results for "TMG (Betaine Anhydrous) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching TMG (Betaine Anhydrous) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: TMG (Betaine Anhydrous) — safety adverse events

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            Live results for "TMG (Betaine Anhydrous) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching TMG (Betaine Anhydrous) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: TMG (Betaine Anhydrous) — dose response

            Live PubMed search

            Live results for "TMG (Betaine Anhydrous) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching TMG (Betaine Anhydrous) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: TMG (Betaine Anhydrous) — clinical evidence

            Live Scholar search

            Cross-database citation index for TMG (Betaine Anhydrous) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.