Overview
Methyl donor for homocysteine reduction.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Methylates homocysteine to methionine.
- · Methylates homocysteine to methionine
Effects on the body
Organ system effects
TMG (Betaine Anhydrous) supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Evidence-based benefits
Lowers homocysteine
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified TMG (Betaine Anhydrous) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.TMG (Betaine Anhydrous) third party tested NSF
CapsulesPre-measured TMG (Betaine Anhydrous) capsules — easiest for travel and consistent daily dosing without scoops or scales.TMG (Betaine Anhydrous) capsules
PowderBulk unflavored TMG (Betaine Anhydrous) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.TMG (Betaine Anhydrous) powder unflavored
Best sellersMost-purchased TMG (Betaine Anhydrous) products on Amazon — a quick way to see what's reviewed widely before you commit.TMG (Betaine Anhydrous) best sellerScientific evidence8Show studiesHide studies
Betaine and power output
Cholewa JM, et al.
23 trained men
Improved cycle sprint power.
PubMed: TMG (Betaine Anhydrous) — Lowers homocysteine
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