Overview
Same as TMG; osmolyte and methyl donor.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Methylates homocysteine; osmoprotectant.
- · Methylates homocysteine
- · osmoprotectant
Effects on the body
Organ system effects
Trimethylglycine (Betaine) supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Trimethylglycine (Betaine) supports hepatocyte antioxidant defenses (glutathione, Nrf2) and phase-I/II detoxification.
Evidence-based benefits
Treats homocystinuria
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
- Milk thistle (silymarin)Complementary hepatoprotective antioxidant pathways.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Trimethylglycine (Betaine) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Trimethylglycine (Betaine) third party tested NSF
CapsulesPre-measured Trimethylglycine (Betaine) capsules — easiest for travel and consistent daily dosing without scoops or scales.Trimethylglycine (Betaine) capsules
PowderBulk unflavored Trimethylglycine (Betaine) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Trimethylglycine (Betaine) powder unflavored
Best sellersMost-purchased Trimethylglycine (Betaine) products on Amazon — a quick way to see what's reviewed widely before you commit.Trimethylglycine (Betaine) best sellerScientific evidence8Show studiesHide studies
Betaine in homocystinuria
Lawson-Yuen A, Levy HL
Clinical review
Effective for cystathionine beta-synthase deficiency.
PubMed: Trimethylglycine (Betaine) — Treats homocystinuria
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Google Scholar: Trimethylglycine (Betaine) — clinical evidence
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