SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

Trimethylglycine (Betaine)

Same as TMG; osmolyte and methyl donor.

Cardiovascular HealthLiver Health

Overview

Same as TMG; osmolyte and methyl donor.

Natural sources
    Common forms

      Mechanism of action

      Methylates homocysteine; osmoprotectant.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Treats homocystinuria

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            3–6 g

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Trimethylgly…
            Amazon
            Wide selection · fast shipping
            Compound
            Trimethylgly…
            iHerb
            Global delivery · curated brands
            Compound
            Trimethylgly…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewMol Genet Metab · 2006

            Betaine in homocystinuria

            Lawson-Yuen A, Levy HL

            Clinical review

            Key findings

            Effective for cystathionine beta-synthase deficiency.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trimethylglycine (Betaine) — Treats homocystinuria

            Live PubMed search

            Live results for "Trimethylglycine (Betaine) Treats homocystinuria" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trimethylglycine (Betaine) and "Treats homocystinuria". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trimethylglycine (Betaine) — randomized controlled trial

            Live PubMed search

            Live results for "Trimethylglycine (Betaine) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trimethylglycine (Betaine) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trimethylglycine (Betaine) — meta-analysis

            Live PubMed search

            Live results for "Trimethylglycine (Betaine) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trimethylglycine (Betaine) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trimethylglycine (Betaine) — pharmacokinetics

            Live PubMed search

            Live results for "Trimethylglycine (Betaine) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trimethylglycine (Betaine) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trimethylglycine (Betaine) — safety adverse events

            Live PubMed search

            Live results for "Trimethylglycine (Betaine) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trimethylglycine (Betaine) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trimethylglycine (Betaine) — dose response

            Live PubMed search

            Live results for "Trimethylglycine (Betaine) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trimethylglycine (Betaine) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Trimethylglycine (Betaine) — clinical evidence

            Live Scholar search

            Cross-database citation index for Trimethylglycine (Betaine) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.