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Supplements/Compound

Rutin

Quercetin-rutinoside for venous health.

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Overview

Quercetin-rutinoside for venous health.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Inhibits PDI; reduces capillary fragility.

Pathways
  • · Inhibits PDI
  • · reduces capillary fragility

Effects on the body

Decreases
hemorrhoid bleeding

Organ system effects

Cardiovascular

Rutin supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.

Evidence-based benefits

Reduces hemorrhoid bleeding

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Rutin use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Omega-3
        Anti-inflammatory cardiovascular synergy.
      • CoQ10
        Supports mitochondrial energetics in cardiac tissue.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500 mg BID
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTPhlebology · 2012

      Rutin in CVI

      Diosmin-rutin trial

      120 CVI patients

      Key findings

      Reduced edema and symptoms.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Rutin — Reduces hemorrhoid bleeding

      Live PubMed search

      Live results for "Rutin Reduces hemorrhoid bleeding" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Rutin and "Reduces hemorrhoid bleeding". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Rutin — randomized controlled trial

      Live PubMed search

      Live results for "Rutin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Rutin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Rutin — meta-analysis

      Live PubMed search

      Live results for "Rutin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Rutin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Rutin — pharmacokinetics

      Live PubMed search

      Live results for "Rutin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Rutin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Rutin — safety adverse events

      Live PubMed search

      Live results for "Rutin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Rutin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Rutin — dose response

      Live PubMed search

      Live results for "Rutin dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Rutin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Rutin — clinical evidence

      Live Scholar search

      Cross-database citation index for Rutin as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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