Overview
Combination stack; see individual Vitamin D3 and Vitamin K2 entries for full details.
- Combined softgel
Mechanism of action
D3 increases intestinal Ca absorption; K2 carboxylates osteocalcin and MGP to direct Ca to bone.
- · VDR signaling
- · Vitamin K-dependent carboxylation
Effects on the body
Organ system effects
Evidence-based benefits
Synergistic for bone & cardiovascular calcium handling
Moderate evidencePotential side effects
Drug interactions
Supplement interactions
- MagnesiumCofactor for vitamin D activation.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Scientific evidence (8)
Vitamin D3 + K2 Synergy Note: pharmacology, clinical evidence, and safety — narrative review
Examine.com Research Team
Curated narrative review of human and preclinical evidence for Vitamin D3 + K2 Synergy Note, including mechanism, typical dosing, and safety considerations.
Best-supported outcome: Synergistic for bone & cardiovascular calcium handling (evidence: moderate). Additional outcomes and limitations summarized in the full profile.
PubMed: Vitamin D3 + K2 Synergy Note — Synergistic for bone & cardiovascular calcium handling
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PubMed: Vitamin D3 + K2 Synergy Note — randomized controlled trial
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PubMed: Vitamin D3 + K2 Synergy Note — meta-analysis
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PubMed: Vitamin D3 + K2 Synergy Note — pharmacokinetics
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PubMed: Vitamin D3 + K2 Synergy Note — safety adverse events
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PubMed: Vitamin D3 + K2 Synergy Note — dose response
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Google Scholar: Vitamin D3 + K2 Synergy Note — clinical evidence
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Cross-database citation index for Vitamin D3 + K2 Synergy Note as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.