Overview
Olive polyphenol for cardiovascular health.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Potent antioxidant; LDL oxidation inhibitor.
- · Potent antioxidant
- · LDL oxidation inhibitor
Effects on the body
Organ system effects
Hydroxytyrosol supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Hydroxytyrosol acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Evidence-based benefits
Reduces LDL oxidation
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Hydroxytyrosol — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Hydroxytyrosol third party tested NSF
CapsulesPre-measured Hydroxytyrosol capsules — easiest for travel and consistent daily dosing without scoops or scales.Hydroxytyrosol capsules
PowderBulk unflavored Hydroxytyrosol powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Hydroxytyrosol powder unflavored
Best sellersMost-purchased Hydroxytyrosol products on Amazon — a quick way to see what's reviewed widely before you commit.Hydroxytyrosol best sellerScientific evidence8Show studiesHide studies
EFSA olive oil polyphenols claim
EFSA Panel
Mechanistic review
Approved health claim: 5 mg/day hydroxytyrosol protects LDL.
PubMed: Hydroxytyrosol — Reduces LDL oxidation
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PubMed: Hydroxytyrosol — randomized controlled trial
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PubMed: Hydroxytyrosol — meta-analysis
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PubMed: Hydroxytyrosol — pharmacokinetics
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PubMed: Hydroxytyrosol — safety adverse events
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PubMed: Hydroxytyrosol — dose response
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Google Scholar: Hydroxytyrosol — clinical evidence
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Cross-database citation index for Hydroxytyrosol as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.