Overview
Cocoa flavanol for follistatin/myostatin.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Inhibits myostatin; activates NO.
- · Inhibits myostatin
- · activates NO
Effects on the body
Organ system effects
(−)-Epicatechin influences muscle protein synthesis, neuromuscular output, or recovery from exercise.
(−)-Epicatechin supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Evidence-based benefits
Improves muscle function
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Creatine monohydrateFoundational support for strength, power, and lean mass.
- Whey or EAAsProvides amino acid substrate for muscle protein synthesis.
- Omega-3Anti-inflammatory cardiovascular synergy.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified (−)-Epicatechin — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.(−)-Epicatechin third party tested NSF
CapsulesPre-measured (−)-Epicatechin capsules — easiest for travel and consistent daily dosing without scoops or scales.(−)-Epicatechin capsules
PowderBulk unflavored (−)-Epicatechin powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.(−)-Epicatechin powder unflavored
Best sellersMost-purchased (−)-Epicatechin products on Amazon — a quick way to see what's reviewed widely before you commit.(−)-Epicatechin best sellerScientific evidence8Show studiesHide studies
Epicatechin and muscle
Gutierrez-Salmean G, et al.
6 elderly
Improved hand grip strength.
PubMed: (−)-Epicatechin — Improves muscle function
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PubMed: (−)-Epicatechin — randomized controlled trial
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PubMed: (−)-Epicatechin — dose response
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Google Scholar: (−)-Epicatechin — clinical evidence
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