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evidence · mechanism · dose
Supplements/Compound

Diosmin + Hesperidin

Citrus flavonoid pair for venous insufficiency.

Cardiovascular Health

Overview

Citrus flavonoid pair for venous insufficiency.

Natural sources
    Common forms

      Mechanism of action

      Increases venous tone; reduces capillary permeability.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves CVI symptoms

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1000 mg/d

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Meta-analysisDrugs · 2003

            MPFF in CVI

            Lyseng-Williamson KA, et al.

            5 RCTs

            Key findings

            Improved leg pain and edema.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Diosmin + Hesperidin — Improves CVI symptoms

            Live PubMed search

            Live results for "Diosmin + Hesperidin Improves CVI symptoms" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Diosmin + Hesperidin and "Improves CVI symptoms". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Diosmin + Hesperidin — randomized controlled trial

            Live PubMed search

            Live results for "Diosmin + Hesperidin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Diosmin + Hesperidin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Diosmin + Hesperidin — meta-analysis

            Live PubMed search

            Live results for "Diosmin + Hesperidin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Diosmin + Hesperidin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Diosmin + Hesperidin — pharmacokinetics

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Diosmin + Hesperidin — safety adverse events

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Diosmin + Hesperidin — dose response

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            Live results for "Diosmin + Hesperidin dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Diosmin + Hesperidin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Diosmin + Hesperidin — clinical evidence

            Live Scholar search

            Cross-database citation index for Diosmin + Hesperidin as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.