Overview
Citrus flavonoid pair for venous insufficiency.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Increases venous tone; reduces capillary permeability.
- · Increases venous tone
- · reduces capillary permeability
Effects on the body
Organ system effects
Diosmin + Hesperidin supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Evidence-based benefits
Improves CVI symptoms
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Diosmin + Hesperidin — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Diosmin + Hesperidin third party tested NSF
CapsulesPre-measured Diosmin + Hesperidin capsules — easiest for travel and consistent daily dosing without scoops or scales.Diosmin + Hesperidin capsules
PowderBulk unflavored Diosmin + Hesperidin powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Diosmin + Hesperidin powder unflavored
Best sellersMost-purchased Diosmin + Hesperidin products on Amazon — a quick way to see what's reviewed widely before you commit.Diosmin + Hesperidin best sellerScientific evidence8Show studiesHide studies
MPFF in CVI
Lyseng-Williamson KA, et al.
5 RCTs
Improved leg pain and edema.
PubMed: Diosmin + Hesperidin — Improves CVI symptoms
Live PubMed search
Live results for "Diosmin + Hesperidin Improves CVI symptoms" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Diosmin + Hesperidin and "Improves CVI symptoms". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Diosmin + Hesperidin — randomized controlled trial
Live PubMed search
Live results for "Diosmin + Hesperidin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Diosmin + Hesperidin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Diosmin + Hesperidin — meta-analysis
Live PubMed search
Live results for "Diosmin + Hesperidin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Diosmin + Hesperidin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Diosmin + Hesperidin — pharmacokinetics
Live PubMed search
Live results for "Diosmin + Hesperidin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Diosmin + Hesperidin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Diosmin + Hesperidin — safety adverse events
Live PubMed search
Live results for "Diosmin + Hesperidin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Diosmin + Hesperidin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Diosmin + Hesperidin — dose response
Live PubMed search
Live results for "Diosmin + Hesperidin dose response" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Diosmin + Hesperidin and "dose response". Filter by RCT, meta-analysis, or year on the results page.
Google Scholar: Diosmin + Hesperidin — clinical evidence
Live Scholar search
Cross-database citation index for Diosmin + Hesperidin as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.