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evidence · mechanism · dose
Supplements/Compound

Lycopene

Tomato carotenoid linked with prostate and cardiovascular protection.

Men's HealthProstate HealthCardiovascular Health

Overview

Tomato carotenoid linked with prostate and cardiovascular protection.

Natural sources
    Common forms

      Mechanism of action

      Potent singlet oxygen quencher; modulates IGF-1 and androgen signaling.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers prostate-specific antigen in BPH/HG-PIN

        Moderate evidence

        Potential side effects

        Common
        • · Skin discoloration at very high intake
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            10–30 mg
            With food?
            With fat

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Lycopene
            Amazon
            Wide selection · fast shipping
            Compound
            Lycopene
            iHerb
            Global delivery · curated brands
            Compound
            Lycopene
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTUrol Oncol · 2005

            Lycopene in HG-PIN

            Mohanty NK, et al.

            1-year RCT in 40 men with HG-PIN.

            Key findings

            4 mg bid lycopene reduced progression to prostate cancer vs control.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lycopene — Lowers prostate-specific antigen in BPH/HG-PIN

            Live PubMed search

            Live results for "Lycopene Lowers prostate-specific antigen in BPH/HG-PIN" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lycopene and "Lowers prostate-specific antigen in BPH/HG-PIN". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lycopene — randomized controlled trial

            Live PubMed search

            Live results for "Lycopene randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lycopene and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lycopene — meta-analysis

            Live PubMed search

            Live results for "Lycopene meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lycopene and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lycopene — pharmacokinetics

            Live PubMed search

            Live results for "Lycopene pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lycopene and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lycopene — safety adverse events

            Live PubMed search

            Live results for "Lycopene safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lycopene and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lycopene — dose response

            Live PubMed search

            Live results for "Lycopene dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lycopene and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Lycopene — clinical evidence

            Live Scholar search

            Cross-database citation index for Lycopene as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.