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evidence · mechanism · dose
Supplements/Fatty Acid

EPA-Dominant Fish Oil

Concentrated EPA for inflammation.

Cardiovascular HealthMood & Anxiety

Overview

Concentrated EPA for inflammation.

Natural sources
    Common forms

      Mechanism of action

      EPA is anti-inflammatory; SPM precursor.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces depression

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        • · Fishy burps
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1–2 g EPA

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Fatty Acid
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            Amazon
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            iHerb
            Global delivery · curated brands
            Fatty Acid
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Meta-analysisTransl Psychiatry · 2016

            EPA for depression

            Mocking RJ, et al.

            13 RCTs

            Key findings

            EPA effective in MDD at >60% EPA.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: EPA-Dominant Fish Oil — Reduces depression

            Live PubMed search

            Live results for "EPA-Dominant Fish Oil Reduces depression" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching EPA-Dominant Fish Oil and "Reduces depression". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: EPA-Dominant Fish Oil — randomized controlled trial

            Live PubMed search

            Live results for "EPA-Dominant Fish Oil randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching EPA-Dominant Fish Oil and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: EPA-Dominant Fish Oil — meta-analysis

            Live PubMed search

            Live results for "EPA-Dominant Fish Oil meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching EPA-Dominant Fish Oil and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: EPA-Dominant Fish Oil — pharmacokinetics

            Live PubMed search

            Live results for "EPA-Dominant Fish Oil pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching EPA-Dominant Fish Oil and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: EPA-Dominant Fish Oil — safety adverse events

            Live PubMed search

            Live results for "EPA-Dominant Fish Oil safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching EPA-Dominant Fish Oil and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: EPA-Dominant Fish Oil — dose response

            Live PubMed search

            Live results for "EPA-Dominant Fish Oil dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching EPA-Dominant Fish Oil and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: EPA-Dominant Fish Oil — clinical evidence

            Live Scholar search

            Cross-database citation index for EPA-Dominant Fish Oil as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.