Overview
Major pomegranate ellagitannin.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Metabolized to urolithins by gut bacteria.
- · Metabolized to urolithins by gut bacteria
Effects on the body
Organ system effects
Punicalagin acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.
Punicalagin supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Evidence-based benefits
Anti-inflammatory
Moderate evidencePotential side effects
- · Well tolerated
Drug interactions
Supplement interactions
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
- Omega-3Lowers inflammation and supports membrane integrity.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Punicalagin — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Punicalagin third party tested NSF
CapsulesPre-measured Punicalagin capsules — easiest for travel and consistent daily dosing without scoops or scales.Punicalagin capsules
PowderBulk unflavored Punicalagin powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Punicalagin powder unflavored
Best sellersMost-purchased Punicalagin products on Amazon — a quick way to see what's reviewed widely before you commit.Punicalagin best sellerScientific evidence8Show studiesHide studies
Punicalagin metabolism
Cerda B, et al.
Pharmacokinetics
Converted to urolithin A in colon.
PubMed: Punicalagin — Anti-inflammatory
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Google Scholar: Punicalagin — clinical evidence
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