SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

Punicalagin

Major pomegranate ellagitannin.

Healthy AgingCardiovascular Health

Overview

Major pomegranate ellagitannin.

Natural sources
    Common forms

      Mechanism of action

      Metabolized to urolithins by gut bacteria.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Anti-inflammatory

        Moderate evidence

        Potential side effects

        Common
        • · Well tolerated
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Punicalagin
            Amazon
            Wide selection · fast shipping
            Compound
            Punicalagin
            iHerb
            Global delivery · curated brands
            Compound
            Punicalagin
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            CohortEur J Nutr · 2004

            Punicalagin metabolism

            Cerda B, et al.

            Pharmacokinetics

            Key findings

            Converted to urolithin A in colon.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Punicalagin — Anti-inflammatory

            Live PubMed search

            Live results for "Punicalagin Anti-inflammatory" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Punicalagin and "Anti-inflammatory". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Punicalagin — randomized controlled trial

            Live PubMed search

            Live results for "Punicalagin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Punicalagin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Punicalagin — meta-analysis

            Live PubMed search

            Live results for "Punicalagin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Punicalagin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Punicalagin — pharmacokinetics

            Live PubMed search

            Live results for "Punicalagin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Punicalagin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Punicalagin — safety adverse events

            Live PubMed search

            Live results for "Punicalagin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Punicalagin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Punicalagin — dose response

            Live PubMed search

            Live results for "Punicalagin dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Punicalagin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Punicalagin — clinical evidence

            Live Scholar search

            Cross-database citation index for Punicalagin as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.