SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

TUDCA

aka Tauroursodeoxycholic acid

Bile acid with hepatoprotective effects and ER stress reduction.

Liver HealthHealthy Aging

Overview

Bile acid with hepatoprotective effects and ER stress reduction.

Natural sources
  • Trace in bear bile (traditional)
Common forms
  • TUDCA capsule

Mechanism of action

Reduces ER stress and apoptosis; protects hepatocytes; mild bile salt.

Pathways
  • · ER stress reduction
  • · Anti-apoptosis

Effects on the body

Supports
Hepatocyte survival
Decreases
ER stress

Organ system effects

Liver

Improves liver enzymes in cholestatic conditions.

Evidence-based benefits

Improves LFTs in cholestasis

Moderate evidence

Used by AAS users for hepatoprotection

Limited evidence

Potential side effects

Common
  • · Diarrhea
Rare
    Serious

      Drug interactions

      Aluminum antacids
      Reduce TUDCA absorption.
      minor

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      250–500 mg/d (general); up to 1500 mg therapeutic

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Compound
      TUDCA
      Amazon
      Wide selection · fast shipping
      Compound
      TUDCA
      iHerb
      Global delivery · curated brands
      Compound
      TUDCA
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (9)

      RCTDig Dis Sci · 1996

      TUDCA improves liver function in chronic hepatitis

      Crosignani A, et al.

      Six-month RCT of TUDCA in chronic hepatitis.

      Key findings

      Significant reductions in ALT/AST vs placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TUDCA — Improves LFTs in cholestasis

      Live PubMed search

      Live results for "TUDCA Improves LFTs in cholestasis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TUDCA and "Improves LFTs in cholestasis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TUDCA — Used by AAS users for hepatoprotection

      Live PubMed search

      Live results for "TUDCA Used by AAS users for hepatoprotection" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TUDCA and "Used by AAS users for hepatoprotection". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TUDCA — randomized controlled trial

      Live PubMed search

      Live results for "TUDCA randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TUDCA and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TUDCA — meta-analysis

      Live PubMed search

      Live results for "TUDCA meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TUDCA and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TUDCA — pharmacokinetics

      Live PubMed search

      Live results for "TUDCA pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TUDCA and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TUDCA — safety adverse events

      Live PubMed search

      Live results for "TUDCA safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TUDCA and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TUDCA — dose response

      Live PubMed search

      Live results for "TUDCA dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TUDCA and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: TUDCA — clinical evidence

      Live Scholar search

      Cross-database citation index for TUDCA as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.