Overview
Standardized silybin-rich extract for liver disease.
- Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
- Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
- Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
- Standardized extract capsule
- Liquid tincture (alcohol or glycerin)
- Powdered whole herb
- Traditional decoction or tea
Forms & variants of Milk Thistle
Different chemical forms of Milk Thistle behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Antioxidant, anti-fibrotic and membrane-stabilizing on hepatocytes.
- · Antioxidant, anti-fibrotic
- · membrane-stabilizing on hepatocytes
Effects on the body
Organ system effects
Silymarin (Liver Dose) supports hepatocyte antioxidant defenses (glutathione, Nrf2) and phase-I/II detoxification.
Evidence-based benefits
Lowers ALT in NAFLD
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
Supplement interactions
- Milk thistle (silymarin)Complementary hepatoprotective antioxidant pathways.
- NACRestores hepatic glutathione.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Silymarin (Liver Dose) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Silymarin (Liver Dose) third party tested NSF
CapsulesPre-measured Silymarin (Liver Dose) capsules — easiest for travel and consistent daily dosing without scoops or scales.Silymarin (Liver Dose) capsules
PowderBulk unflavored Silymarin (Liver Dose) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Silymarin (Liver Dose) powder unflavored
Best sellersMost-purchased Silymarin (Liver Dose) products on Amazon — a quick way to see what's reviewed widely before you commit.Silymarin (Liver Dose) best sellerScientific evidence8Show studiesHide studies
Silymarin in NAFLD
Wah Kheong C, et al.
48-week DB-RCT in 99 NASH patients.
Improved fibrosis score on liver biopsy vs placebo.
PubMed: Silymarin (Liver Dose) — Lowers ALT in NAFLD
Live PubMed search
Live results for "Silymarin (Liver Dose) Lowers ALT in NAFLD" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Silymarin (Liver Dose) and "Lowers ALT in NAFLD". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Silymarin (Liver Dose) — randomized controlled trial
Live PubMed search
Live results for "Silymarin (Liver Dose) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Silymarin (Liver Dose) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Silymarin (Liver Dose) — meta-analysis
Live PubMed search
Live results for "Silymarin (Liver Dose) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Silymarin (Liver Dose) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Silymarin (Liver Dose) — pharmacokinetics
Live PubMed search
Live results for "Silymarin (Liver Dose) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Silymarin (Liver Dose) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Silymarin (Liver Dose) — safety adverse events
Live PubMed search
Live results for "Silymarin (Liver Dose) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Silymarin (Liver Dose) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Silymarin (Liver Dose) — dose response
Live PubMed search
Live results for "Silymarin (Liver Dose) dose response" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Silymarin (Liver Dose) and "dose response". Filter by RCT, meta-analysis, or year on the results page.
Google Scholar: Silymarin (Liver Dose) — clinical evidence
Live Scholar search
Cross-database citation index for Silymarin (Liver Dose) as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.