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evidence · mechanism · dose
Supplements/Herb

Silymarin (Liver Dose)

Standardized silybin-rich extract for liver disease.

Liver Health

Overview

Standardized silybin-rich extract for liver disease.

Natural sources
    Common forms

      Forms & variants of Milk Thistle

      Different chemical forms of Milk Thistle behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Milk Thistle

      Hepatoprotective herb with antioxidant and anti-fibrotic effects.

      Mechanism of action

      Antioxidant, anti-fibrotic and membrane-stabilizing on hepatocytes.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers ALT in NAFLD

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            420 mg silymarin/day
            With food?
            With meals

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTClin Gastroenterol Hepatol · 2017

            Silymarin in NAFLD

            Wah Kheong C, et al.

            48-week DB-RCT in 99 NASH patients.

            Key findings

            Improved fibrosis score on liver biopsy vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Silymarin (Liver Dose) — Lowers ALT in NAFLD

            Live PubMed search

            Live results for "Silymarin (Liver Dose) Lowers ALT in NAFLD" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Silymarin (Liver Dose) and "Lowers ALT in NAFLD". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Silymarin (Liver Dose) — randomized controlled trial

            Live PubMed search

            Live results for "Silymarin (Liver Dose) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Silymarin (Liver Dose) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Silymarin (Liver Dose) — meta-analysis

            Live PubMed search

            Live results for "Silymarin (Liver Dose) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Silymarin (Liver Dose) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Silymarin (Liver Dose) — pharmacokinetics

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            Live results for "Silymarin (Liver Dose) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Silymarin (Liver Dose) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Silymarin (Liver Dose) — safety adverse events

            Live PubMed search

            Live results for "Silymarin (Liver Dose) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Silymarin (Liver Dose) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Silymarin (Liver Dose) — dose response

            Live PubMed search

            Live results for "Silymarin (Liver Dose) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Silymarin (Liver Dose) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Silymarin (Liver Dose) — clinical evidence

            Live Scholar search

            Cross-database citation index for Silymarin (Liver Dose) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.