Overview
Non-absorbable disaccharide for constipation and HE.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Osmotic laxative; converted to lactic acid in colon, traps ammonia.
- · Osmotic laxative
- · converted to lactic acid in colon, traps ammonia
Effects on the body
Organ system effects
Lactulose influences gut motility, mucosal integrity, or microbial balance in the GI tract.
Lactulose supports hepatocyte antioxidant defenses (glutathione, Nrf2) and phase-I/II detoxification.
Evidence-based benefits
Treats constipation and hepatic encephalopathy
Moderate evidencePotential side effects
- · Bloating
- · Diarrhea
Drug interactions
Supplement interactions
- Multi-strain probioticSupports microbiome diversity and barrier integrity.
- L-glutamineSubstrate for enterocyte energy and tight-junction maintenance.
- Milk thistle (silymarin)Complementary hepatoprotective antioxidant pathways.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Lactulose — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Lactulose third party tested NSF
CapsulesPre-measured Lactulose capsules — easiest for travel and consistent daily dosing without scoops or scales.Lactulose capsules
PowderBulk unflavored Lactulose powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Lactulose powder unflavored
Best sellersMost-purchased Lactulose products on Amazon — a quick way to see what's reviewed widely before you commit.Lactulose best sellerScientific evidence8Show studiesHide studies
Lactulose in hepatic encephalopathy
Sharma BC, et al.
125 cirrhotic patients
Reduced HE recurrence vs placebo.
PubMed: Lactulose — Treats constipation and hepatic encephalopathy
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Google Scholar: Lactulose — clinical evidence
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