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evidence · mechanism · dose
Supplements/Compound

S-Acetyl Glutathione

Acetylated GSH — stable through the gut and converted intracellularly to glutathione.

Liver HealthHealthy Aging

Overview

Acetylated GSH — stable through the gut and converted intracellularly to glutathione.

Natural sources
    Common forms

      Forms & variants of Glutathione

      Different chemical forms of Glutathione behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Glutathione

      Master intracellular antioxidant; oral bioavailability depends on form.

      Liposomal
      Liposomal Glutathione

      Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.

      Mechanism of action

      Acetyl group blocks peptidase cleavage until intracellular esterases release GSH.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Raises intracellular GSH (small trial)

        Limited evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              100–300 mg
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              S-Acetyl Glu…
              Amazon
              Wide selection · fast shipping
              Compound
              S-Acetyl Glu…
              iHerb
              Global delivery · curated brands
              Compound
              S-Acetyl Glu…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTRedox Biol · 2015

              S-acetyl glutathione vs reduced glutathione bioavailability

              Schmitt B, et al.

              Crossover trial of GSH forms.

              Key findings

              S-acetyl form better preserved through GI tract.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: S-Acetyl Glutathione — Raises intracellular GSH

              Live PubMed search

              Live results for "S-Acetyl Glutathione Raises intracellular GSH" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching S-Acetyl Glutathione and "Raises intracellular GSH". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: S-Acetyl Glutathione — randomized controlled trial

              Live PubMed search

              Live results for "S-Acetyl Glutathione randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching S-Acetyl Glutathione and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: S-Acetyl Glutathione — meta-analysis

              Live PubMed search

              Live results for "S-Acetyl Glutathione meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching S-Acetyl Glutathione and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: S-Acetyl Glutathione — pharmacokinetics

              Live PubMed search

              Live results for "S-Acetyl Glutathione pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching S-Acetyl Glutathione and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: S-Acetyl Glutathione — safety adverse events

              Live PubMed search

              Live results for "S-Acetyl Glutathione safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching S-Acetyl Glutathione and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: S-Acetyl Glutathione — dose response

              Live PubMed search

              Live results for "S-Acetyl Glutathione dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching S-Acetyl Glutathione and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: S-Acetyl Glutathione — clinical evidence

              Live Scholar search

              Cross-database citation index for S-Acetyl Glutathione as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.