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evidence · mechanism · dose
Supplements/Compound

Calcium D-Glucarate

Beta-glucuronidase inhibitor promoting elimination of conjugated hormones/toxins.

Liver HealthHormone Optimization

Overview

Beta-glucuronidase inhibitor promoting elimination of conjugated hormones/toxins.

Natural sources
  • Oranges
  • Apples
  • Cruciferous
Common forms
  • Calcium D-glucarate

Mechanism of action

Inhibits β-glucuronidase, reducing deconjugation and reabsorption in gut.

Pathways
  • · Phase II conjugation maintenance

Effects on the body

Supports
Hormone/toxin elimination

Organ system effects

Liver

May reduce estrogen reabsorption.

Evidence-based benefits

Reduces beta-glucuronidase activity

Limited evidence

Potential side effects

Common
    Rare
      Serious

        Drug interactions

        No notable interactions reported.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        500–1500 mg/d

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
        Calcium D-Gl…
        Amazon
        Wide selection · fast shipping
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        iHerb
        Global delivery · curated brands
        Compound
        Calcium D-Gl…
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        AnimalCancer Detect Prev · 1990

        Calcium-D-glucarate and beta-glucuronidase

        Walaszek Z, et al.

        Preclinical work on calcium-D-glucarate.

        Key findings

        Inhibits beta-glucuronidase; preclinical chemopreventive effects.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Calcium D-Glucarate — Reduces beta-glucuronidase activity

        Live PubMed search

        Live results for "Calcium D-Glucarate Reduces beta-glucuronidase activity" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Calcium D-Glucarate and "Reduces beta-glucuronidase activity". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Calcium D-Glucarate — randomized controlled trial

        Live PubMed search

        Live results for "Calcium D-Glucarate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Calcium D-Glucarate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Calcium D-Glucarate — meta-analysis

        Live PubMed search

        Live results for "Calcium D-Glucarate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Calcium D-Glucarate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Calcium D-Glucarate — pharmacokinetics

        Live PubMed search

        Live results for "Calcium D-Glucarate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Calcium D-Glucarate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Calcium D-Glucarate — safety adverse events

        Live PubMed search

        Live results for "Calcium D-Glucarate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Calcium D-Glucarate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Calcium D-Glucarate — dose response

        Live PubMed search

        Live results for "Calcium D-Glucarate dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Calcium D-Glucarate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Calcium D-Glucarate — clinical evidence

        Live Scholar search

        Cross-database citation index for Calcium D-Glucarate as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.