Overview
Beta-glucuronidase inhibitor promoting elimination of conjugated hormones/toxins.
- Oranges
- Apples
- Cruciferous
- Calcium D-glucarate
Mechanism of action
Inhibits β-glucuronidase, reducing deconjugation and reabsorption in gut.
- · Phase II conjugation maintenance
Effects on the body
Organ system effects
May reduce estrogen reabsorption.
Evidence-based benefits
Reduces beta-glucuronidase activity
Limited evidencePotential side effects
- · Calcium D-Glucarate is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Supplement interactions
- Milk thistle (silymarin)Complementary hepatoprotective antioxidant pathways.
- NACRestores hepatic glutathione.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Calcium D-Glucarate — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Calcium D-Glucarate third party tested NSF
CapsulesPre-measured Calcium D-Glucarate capsules — easiest for travel and consistent daily dosing without scoops or scales.Calcium D-Glucarate capsules
PowderBulk unflavored Calcium D-Glucarate powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Calcium D-Glucarate powder unflavored
Best sellersMost-purchased Calcium D-Glucarate products on Amazon — a quick way to see what's reviewed widely before you commit.Calcium D-Glucarate best sellerScientific evidence8Show studiesHide studies
Calcium-D-glucarate and beta-glucuronidase
Walaszek Z, et al.
Preclinical work on calcium-D-glucarate.
Inhibits beta-glucuronidase; preclinical chemopreventive effects.
PubMed: Calcium D-Glucarate — Reduces beta-glucuronidase activity
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PubMed: Calcium D-Glucarate — randomized controlled trial
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PubMed: Calcium D-Glucarate — dose response
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Google Scholar: Calcium D-Glucarate — clinical evidence
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