Hormone Optimization
Endocrine support across HPG/HPA axes.
Ranked by evidence strength across reported benefits.
Vitamin D3
Steroid hormone precursor regulating ~5% of the human genome — bone, immune, and hormonal health.
Chasteberry (Vitex)
Dopaminergic herb reducing prolactin and improving PMS/luteal phase symptoms.
Iodine
Halogen essential for thyroid hormone synthesis.
Selenium-Iodine Synergy (note)
See individual selenium and iodine entries; balance is critical for thyroid health.
Iodine (Thyroid Optimization)
Essential thyroid hormone substrate — careful dosing required in autoimmunity.
Potassium Iodide
Standard inorganic iodine — thyroid hormone precursor and radioprotectant.
Tongkat Ali
Malaysian root extract that frees bound testosterone via SHBG reduction.
DHEA
Adrenal androgen precursor declining with age; used for adrenal insufficiency and aging.
DIM (Diindolylmethane)
Cruciferous-derived compound modulating estrogen metabolism toward 2-OH pathway.
DIM (Diindolylmethane)
Cruciferous-vegetable metabolite that shifts estrogen metabolism toward 2-OH (protective) pathways.
Selenium
Trace mineral essential for glutathione peroxidase and thyroid hormone activation.
Saw Palmetto
Lipidosterolic extract used for BPH urinary symptoms.
Stinging Nettle Root
Herbal for BPH and SHBG modulation, often paired with saw palmetto.
Selenomethionine
Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.
Boron
Trace mineral implicated in steroid hormone metabolism and bone integrity.
Pregnenolone
Master steroid precursor; small doses studied for cognition and PTSD.
Calcium D-Glucarate
Beta-glucuronidase inhibitor promoting elimination of conjugated hormones/toxins.
Calcium-D-Glucarate
Inhibits β-glucuronidase to support estrogen and toxin elimination via the liver.
Ashwagandha (Thyroid Support)
Supports T4→T3 conversion in subclinical hypothyroid adults.