Overview
Cruciferous-vegetable metabolite that shifts estrogen metabolism toward 2-OH (protective) pathways.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Modulates cytochrome P450 (CYP1A1/CYP1B1) ratio, favoring 2-hydroxyestrone over 16α-hydroxyestrone.
- · CYP1A1 induction
- · AhR activation
- · 2:16 OH-estrone ratio
Effects on the body
Organ system effects
DIM (Diindolylmethane) influences androgen signaling, prostate health, or male reproductive function.
Evidence-based benefits
Improves 2:16 OH estrogen ratio
Moderate evidenceReduces cyclical mastalgia
Limited evidencePotential side effects
- · Dark urine
- · Headache
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Hormone-sensitive cancers (breast, prostate, ovarian, uterine)
- ·Hormonal contraceptives, HRT, tamoxifen, aromatase inhibitors
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified DIM (Diindolylmethane) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.DIM (Diindolylmethane) third party tested NSF
CapsulesPre-measured DIM (Diindolylmethane) capsules — easiest for travel and consistent daily dosing without scoops or scales.DIM (Diindolylmethane) capsules
PowderBulk unflavored DIM (Diindolylmethane) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.DIM (Diindolylmethane) powder unflavored
Best sellersMost-purchased DIM (Diindolylmethane) products on Amazon — a quick way to see what's reviewed widely before you commit.DIM (Diindolylmethane) best sellerScientific evidence9Show studiesHide studies
DIM and estrogen metabolism
Reed GA, et al.
30-day RCT of BR-DIM in postmenopausal women.
Favorable shift in 2-OH/16-OH estrogen ratio.
PubMed: DIM (Diindolylmethane) — Improves 2:16 OH estrogen ratio
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PubMed: DIM (Diindolylmethane) — Reduces cyclical mastalgia
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Google Scholar: DIM (Diindolylmethane) — clinical evidence
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