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evidence · mechanism · dose
Supplements/Herb

Stinging Nettle Root

aka Urtica dioica

Herbal for BPH and SHBG modulation, often paired with saw palmetto.

Men's HealthHormone Optimization

Overview

Herbal for BPH and SHBG modulation, often paired with saw palmetto.

Natural sources
  • Urtica dioica root
Common forms
  • Standardized extract

Mechanism of action

Beta-sitosterol and lectins; may inhibit SHBG-DHT binding.

Pathways
  • · SHBG modulation

Effects on the body

Decreases
BPH symptoms

Organ system effects

Reproductive

Combined with saw palmetto for BPH.

Evidence-based benefits

Improves BPH urinary flow

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Antihypertensives / antidiabetics
      Additive.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      300–600 mg standardized

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Herb
      Stinging Net…
      Amazon
      Wide selection · fast shipping
      Herb
      Stinging Net…
      iHerb
      Global delivery · curated brands
      Herb
      Stinging Net…
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      RCTJ Herb Pharmacother · 2005

      Urtica dioica root for benign prostatic hyperplasia

      Safarinejad MR

      6-month RCT of nettle root in BPH.

      Key findings

      Improved IPSS and peak flow vs placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stinging Nettle Root — Improves BPH urinary flow

      Live PubMed search

      Live results for "Stinging Nettle Root Improves BPH urinary flow" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stinging Nettle Root and "Improves BPH urinary flow". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stinging Nettle Root — randomized controlled trial

      Live PubMed search

      Live results for "Stinging Nettle Root randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stinging Nettle Root and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stinging Nettle Root — meta-analysis

      Live PubMed search

      Live results for "Stinging Nettle Root meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stinging Nettle Root and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stinging Nettle Root — pharmacokinetics

      Live PubMed search

      Live results for "Stinging Nettle Root pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stinging Nettle Root and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stinging Nettle Root — safety adverse events

      Live PubMed search

      Live results for "Stinging Nettle Root safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stinging Nettle Root and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stinging Nettle Root — dose response

      Live PubMed search

      Live results for "Stinging Nettle Root dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stinging Nettle Root and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Stinging Nettle Root — clinical evidence

      Live Scholar search

      Cross-database citation index for Stinging Nettle Root as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.