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evidence · mechanism · dose
Supplements/Mineral

Iodine (Thyroid Optimization)

Essential thyroid hormone substrate — careful dosing required in autoimmunity.

Thyroid SupportHormone Optimization

Overview

Essential thyroid hormone substrate — careful dosing required in autoimmunity.

Natural sources
    Common forms

      Mechanism of action

      Concentrated by NIS; iodinated tyrosine forms T4/T3.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Corrects iodine deficiency goiter

        Strong evidence

        Potential side effects

        Common
          Rare
          • · Hashimoto flare
          Serious
          • · Iodine-induced hyper/hypothyroidism

          Drug interactions

          No notable interactions reported.

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          150 mcg RDA; 250 mcg in pregnancy
          Upper safe limit
          1100 mcg/d
          With food?
          Optional

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          Systematic reviewNat Rev Endocrinol · 2013

          Iodine supplementation in mild-to-moderate deficiency

          Pearce EN, et al.

          Review of iodine repletion strategies.

          Key findings

          Restores thyroid function and prevents goiter.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Iodine (Thyroid Optimization) — Corrects iodine deficiency goiter

          Live PubMed search

          Live results for "Iodine (Thyroid Optimization) Corrects iodine deficiency goiter" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "Corrects iodine deficiency goiter". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Iodine (Thyroid Optimization) — randomized controlled trial

          Live PubMed search

          Live results for "Iodine (Thyroid Optimization) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Iodine (Thyroid Optimization) — meta-analysis

          Live PubMed search

          Live results for "Iodine (Thyroid Optimization) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Iodine (Thyroid Optimization) — pharmacokinetics

          Live PubMed search

          Live results for "Iodine (Thyroid Optimization) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Iodine (Thyroid Optimization) — safety adverse events

          Live PubMed search

          Live results for "Iodine (Thyroid Optimization) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Iodine (Thyroid Optimization) — dose response

          Live PubMed search

          Live results for "Iodine (Thyroid Optimization) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Iodine (Thyroid Optimization) — clinical evidence

          Live Scholar search

          Cross-database citation index for Iodine (Thyroid Optimization) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.