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Supplements/Mineral

Iodine (Thyroid Optimization)

Essential thyroid hormone substrate — careful dosing required in autoimmunity.

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Overview

Essential thyroid hormone substrate — careful dosing required in autoimmunity.

Natural sources
  • Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)
  • Fortified foods such as cereals, breads, plant milks, and table salt
  • Mineral supplements as chelates, citrates, glycinates, or inorganic salts
Common forms
  • Chelated form (glycinate, bisglycinate, citrate, malate)
  • Inorganic salt (oxide, sulfate, chloride)
  • Liquid ionic solution
  • Topical or transdermal preparation

Mechanism of action

Concentrated by NIS; iodinated tyrosine forms T4/T3.

Pathways
  • · Concentrated by NIS
  • · iodinated tyrosine forms T4/T3

Effects on the body

Supports
Corrects iodine deficiency goiter

Organ system effects

Evidence-based benefits

Corrects iodine deficiency goiter

Strong evidence

Potential side effects

Common
    Rare
    • · Hashimoto flare
    Serious
    • · Iodine-induced hyper/hypothyroidism

    Drug interactions

    Prescription medications (general)
    Always disclose Iodine (Thyroid Optimization) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
    minor

    Supplement interactions

    Pairs well with
    • A high-quality multivitamin
      Covers micronutrient cofactors that support most supplement pathways.
    • Omega-3 (EPA/DHA)
      Foundational anti-inflammatory support that complements most regimens.
    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    150 mcg RDA; 250 mcg in pregnancy
    Upper safe limit
    1100 mcg/d
    Best form
    Most evidence is based on the chelated form (glycinate, bisglycinate, citrate, malate) form.
    Timing
    Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
    With food?
    Optional

    Where to buy

    Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Scientific evidence8Show studies
    Systematic reviewNat Rev Endocrinol · 2013

    Iodine supplementation in mild-to-moderate deficiency

    Pearce EN, et al.

    Review of iodine repletion strategies.

    Key findings

    Restores thyroid function and prevents goiter.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iodine (Thyroid Optimization) — Corrects iodine deficiency goiter

    Live PubMed search

    Live results for "Iodine (Thyroid Optimization) Corrects iodine deficiency goiter" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "Corrects iodine deficiency goiter". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iodine (Thyroid Optimization) — randomized controlled trial

    Live PubMed search

    Live results for "Iodine (Thyroid Optimization) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iodine (Thyroid Optimization) — meta-analysis

    Live PubMed search

    Live results for "Iodine (Thyroid Optimization) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iodine (Thyroid Optimization) — pharmacokinetics

    Live PubMed search

    Live results for "Iodine (Thyroid Optimization) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iodine (Thyroid Optimization) — safety adverse events

    Live PubMed search

    Live results for "Iodine (Thyroid Optimization) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iodine (Thyroid Optimization) — dose response

    Live PubMed search

    Live results for "Iodine (Thyroid Optimization) dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iodine (Thyroid Optimization) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Iodine (Thyroid Optimization) — clinical evidence

    Live Scholar search

    Cross-database citation index for Iodine (Thyroid Optimization) as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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