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evidence · mechanism · dose
Supplements/Mineral

Selenium-Iodine Synergy (note)

See individual selenium and iodine entries; balance is critical for thyroid health.

Hormone Optimization

Overview

Iodine is the substrate for T4/T3; selenium activates these via deiodinases. Imbalance worsens Hashimoto's.

Natural sources
    Common forms

      Mechanism of action

      Iodine = thyroid hormone substrate; selenium = activator and GPx cofactor in thyroid.

      Pathways
      • · Thyroid hormone synthesis and activation

      Effects on the body

      Organ system effects

      Endocrine

      Both required; deficiency or excess of either is harmful.

      Evidence-based benefits

      Combined adequacy supports thyroid function

      Strong evidence

      Potential side effects

      Common
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            150 mcg iodine + 100–200 mcg selenium

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Mineral
            Selenium-Iod…
            Amazon
            Wide selection · fast shipping
            Mineral
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            iHerb
            Global delivery · curated brands
            Mineral
            Selenium-Iod…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewDermatol Ther · 2013

            Povidone-iodine antiseptic activity

            Lachapelle JM, et al.

            Review of PVP-I antimicrobial efficacy.

            Key findings

            Broad spectrum; reduces SSI when used preoperatively.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium-Iodine Synergy (note) — Combined adequacy supports thyroid function

            Live PubMed search

            Live results for "Selenium-Iodine Synergy (note) Combined adequacy supports thyroid function" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium-Iodine Synergy (note) and "Combined adequacy supports thyroid function". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium-Iodine Synergy (note) — randomized controlled trial

            Live PubMed search

            Live results for "Selenium-Iodine Synergy (note) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium-Iodine Synergy (note) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium-Iodine Synergy (note) — meta-analysis

            Live PubMed search

            Live results for "Selenium-Iodine Synergy (note) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium-Iodine Synergy (note) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium-Iodine Synergy (note) — pharmacokinetics

            Live PubMed search

            Live results for "Selenium-Iodine Synergy (note) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium-Iodine Synergy (note) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium-Iodine Synergy (note) — safety adverse events

            Live PubMed search

            Live results for "Selenium-Iodine Synergy (note) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium-Iodine Synergy (note) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Selenium-Iodine Synergy (note) — dose response

            Live PubMed search

            Live results for "Selenium-Iodine Synergy (note) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Selenium-Iodine Synergy (note) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Selenium-Iodine Synergy (note) — clinical evidence

            Live Scholar search

            Cross-database citation index for Selenium-Iodine Synergy (note) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.