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Supplements/Mineral

Molybdenum (Extra)

Cofactor for sulfite oxidase and aldehyde dehydrogenase.

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Overview

Cofactor for sulfite oxidase and aldehyde dehydrogenase.

Natural sources
  • Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)
  • Fortified foods such as cereals, breads, plant milks, and table salt
  • Mineral supplements as chelates, citrates, glycinates, or inorganic salts
Common forms
  • Chelated form (glycinate, bisglycinate, citrate, malate)
  • Inorganic salt (oxide, sulfate, chloride)
  • Liquid ionic solution
  • Topical or transdermal preparation

Forms & variants of Molybdenum

Different chemical forms of Molybdenum behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Mechanism of action

Required by molybdoenzymes that metabolize sulfites, purines, and aldehydes.

Pathways
  • · Required by molybdoenzymes that metabolize sulfites, purines
  • · and aldehydes

Effects on the body

Supports
sulfite metabolism in MoCD/SSD

Organ system effects

Liver

Molybdenum (Extra) supports hepatocyte antioxidant defenses (glutathione, Nrf2) and phase-I/II detoxification.

Evidence-based benefits

Supports sulfite metabolism in MoCD/SSD

Strong evidence

Potential side effects

Common
    Rare
    • · Gout flare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Molybdenum (Extra) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Milk thistle (silymarin)
        Complementary hepatoprotective antioxidant pathways.
      • NAC
        Restores hepatic glutathione.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      75–150 mcg
      Best form
      Most evidence is based on the chelated form (glycinate, bisglycinate, citrate, malate) form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      CohortLancet · 2010

      Molybdenum cofactor in MoCD

      Schwarz G, et al.

      Compassionate-use trial in infants with MoCD-A.

      Key findings

      Substrate replacement reduced neurological deterioration.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Molybdenum (Extra) — Supports sulfite metabolism in MoCD/SSD

      Live PubMed search

      Live results for "Molybdenum (Extra) Supports sulfite metabolism in MoCD/SSD" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Molybdenum (Extra) and "Supports sulfite metabolism in MoCD/SSD". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Molybdenum (Extra) — randomized controlled trial

      Live PubMed search

      Live results for "Molybdenum (Extra) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Molybdenum (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Molybdenum (Extra) — meta-analysis

      Live PubMed search

      Live results for "Molybdenum (Extra) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Molybdenum (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Molybdenum (Extra) — pharmacokinetics

      Live PubMed search

      Live results for "Molybdenum (Extra) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Molybdenum (Extra) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Molybdenum (Extra) — safety adverse events

      Live PubMed search

      Live results for "Molybdenum (Extra) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Molybdenum (Extra) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Molybdenum (Extra) — dose response

      Live PubMed search

      Live results for "Molybdenum (Extra) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Molybdenum (Extra) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Molybdenum (Extra) — clinical evidence

      Live Scholar search

      Cross-database citation index for Molybdenum (Extra) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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