Overview
Universal methyl donor with antidepressant and liver-supportive evidence.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Donates methyl groups for neurotransmitter and phospholipid synthesis.
- · Donates methyl groups for neurotransmitter
- · phospholipid synthesis
Effects on the body
Organ system effects
SAMe (S-Adenosyl Methionine) supports hepatocyte antioxidant defenses (glutathione, Nrf2) and phase-I/II detoxification.
Evidence-based benefits
Comparable to imipramine in depression
Moderate evidenceImproves intrahepatic cholestasis
Moderate evidencePotential side effects
- · Nausea
- · Insomnia
- · Mania (bipolar)
- · Serotonin syndrome with SSRIs
Drug interactions
Supplement interactions
- Milk thistle (silymarin)Complementary hepatoprotective antioxidant pathways.
- NACRestores hepatic glutathione.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified SAMe (S-Adenosyl Methionine) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.SAMe (S-Adenosyl Methionine) third party tested NSF
CapsulesPre-measured SAMe (S-Adenosyl Methionine) capsules — easiest for travel and consistent daily dosing without scoops or scales.SAMe (S-Adenosyl Methionine) capsules
PowderBulk unflavored SAMe (S-Adenosyl Methionine) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.SAMe (S-Adenosyl Methionine) powder unflavored
Best sellersMost-purchased SAMe (S-Adenosyl Methionine) products on Amazon — a quick way to see what's reviewed widely before you commit.SAMe (S-Adenosyl Methionine) best sellerScientific evidence9Show studiesHide studies
SAMe for depression: a meta-analysis
Galizia I, et al.
Cochrane review of SAMe in MDD.
Comparable to imipramine for moderate depression.
PubMed: SAMe (S-Adenosyl Methionine) — Comparable to imipramine in depression
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PubMed: SAMe (S-Adenosyl Methionine) — Improves intrahepatic cholestasis
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Google Scholar: SAMe (S-Adenosyl Methionine) — clinical evidence
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