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evidence · mechanism · dose
Supplements/Compound

Sulforaphane (Broccoli Sprout)

Most potent natural Nrf2 activator — upregulates phase II detox enzymes.

AntioxidantsLongevity PathwaysLiver HealthDNA Protection

Overview

Most potent natural Nrf2 activator — upregulates phase II detox enzymes.

Natural sources
    Common forms

      Mechanism of action

      Activates Nrf2/ARE pathway, inducing glutathione, NQO1, HO-1.

      Pathways
      • · Nrf2/ARE
      • · Phase II detoxification

      Effects on the body

      Organ system effects

      Evidence-based benefits

      Reduces oxidative stress markers

      Moderate evidence

      Possible autism behavioral benefits

      Limited evidence

      Potential side effects

      Common
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            10–40 mg sulforaphane (or fresh broccoli sprouts)
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Sulforaphane…
            Amazon
            Wide selection · fast shipping
            Compound
            Sulforaphane…
            iHerb
            Global delivery · curated brands
            Compound
            Sulforaphane…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            Systematic reviewOxid Med Cell Longev · 2016

            Sulforaphane on Nrf2 activation and oxidative stress

            Houghton CA, et al.

            Review of broccoli sprout sulforaphane clinical trials.

            Key findings

            Induces Nrf2-target genes; benefits in autism, T2D, and asthma.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sulforaphane (Broccoli Sprout) — Reduces oxidative stress markers

            Live PubMed search

            Live results for "Sulforaphane (Broccoli Sprout) Reduces oxidative stress markers" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sulforaphane (Broccoli Sprout) and "Reduces oxidative stress markers". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sulforaphane (Broccoli Sprout) — Possible autism behavioral benefits

            Live PubMed search

            Live results for "Sulforaphane (Broccoli Sprout) Possible autism behavioral benefits" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sulforaphane (Broccoli Sprout) and "Possible autism behavioral benefits". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sulforaphane (Broccoli Sprout) — randomized controlled trial

            Live PubMed search

            Live results for "Sulforaphane (Broccoli Sprout) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sulforaphane (Broccoli Sprout) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sulforaphane (Broccoli Sprout) — meta-analysis

            Live PubMed search

            Live results for "Sulforaphane (Broccoli Sprout) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sulforaphane (Broccoli Sprout) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sulforaphane (Broccoli Sprout) — pharmacokinetics

            Live PubMed search

            Live results for "Sulforaphane (Broccoli Sprout) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sulforaphane (Broccoli Sprout) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sulforaphane (Broccoli Sprout) — safety adverse events

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            Live results for "Sulforaphane (Broccoli Sprout) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sulforaphane (Broccoli Sprout) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sulforaphane (Broccoli Sprout) — dose response

            Live PubMed search

            Live results for "Sulforaphane (Broccoli Sprout) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sulforaphane (Broccoli Sprout) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Sulforaphane (Broccoli Sprout) — clinical evidence

            Live Scholar search

            Cross-database citation index for Sulforaphane (Broccoli Sprout) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.