Antioxidants
ROS quenching and redox support.
Ranked by evidence strength across reported benefits.
Vitamin D3
Steroid hormone precursor regulating ~5% of the human genome — bone, immune, and hormonal health.
Melatonin
Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.
Coffee
Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.
N-Acetyl Cysteine (NAC)
Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.
Vitamin A (Retinol)
Fat-soluble vitamin essential for vision, immune function, and epithelial integrity.
Vitamin B3 (Niacin)
NAD+ precursor; nicotinic acid form lowers LDL and raises HDL.
Vitamin C
Water-soluble antioxidant, collagen cofactor, and immune supporter.
Milk Thistle
Hepatoprotective herb with antioxidant and anti-fibrotic effects.
Garlic
Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.
Lactobacillus Probiotics
Lactic acid bacteria supporting gut barrier, immunity, and women's urogenital health.
Beta-Glucan
Polysaccharide that primes innate immune cells (yeast) or lowers cholesterol (oat).
Glycine
Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.
Vitamin D3 (Cholecalciferol)
Preferred form for raising 25(OH)D — the active form your skin makes from sun.
Aged Garlic Extract (Kyolic)
Odorless aged garlic with S-allyl-cysteine for vascular health.
Nicotinamide Riboside (NR)
NAD+ precursor with bioavailability and longevity research interest.
NMN
NAD+ precursor similar to NR; bioavailability route debated.
Milk Thistle (Liver)
Silymarin — most-studied liver herb, used for ALD, NAFLD, and toxin protection.
Nicotinamide Riboside (NR)
NAD+ precursor that bypasses the flush — studied for cellular aging.
Turkey Tail
Beta-glucan-rich mushroom used as immune adjunct in cancer (PSK approved in Japan).
Saccharomyces Boulardii
Beneficial yeast used to prevent and treat several types of diarrhea.
Alpha-Lipoic Acid
Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.
Andrographis
Bitter herb with strong RCT evidence for URI symptom reduction.
Lutein + Zeaxanthin
Macular xanthophylls — protect retina from blue light and oxidative damage.
Zinc Gluconate
Most common over-the-counter zinc form — affordable, moderate bioavailability.
Idebenone
Synthetic CoQ10 analog with better water solubility; used in LHON.
Andrographis (KalmCold)
Standardized andrographolide for acute upper respiratory infections.
Pelargonium sidoides (Umckaloabo)
South African geranium root for acute bronchitis and URIs.
Vitamin D3 (Maintenance)
Daily maintenance dose for non-deficient adults.
Vitamin D3 (Repletion)
Repletion dose for deficiency under medical supervision.
Selenium-Enriched Yeast
Yeast-bound selenomethionine — form used in major chemoprevention trials.
ALA (R-isomer)
Natural enantiomer of α-lipoic acid with better bioavailability.
Zinc
Cofactor for ~300 enzymes — critical for testosterone, immune function, and DNA synthesis.
Vitamin K2 (MK-7)
Activates the proteins that direct calcium into bone — not arteries.
Coenzyme Q10
Mitochondrial electron carrier and lipid-soluble antioxidant.
Glycine
Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
Vitamin E
Primary lipid-phase antioxidant protecting membrane PUFAs.
L-Glutamine
Most abundant amino acid; primary fuel for enterocytes and immune cells.
American Ginseng
Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.
Pomegranate
Polyphenol-rich fruit converted by gut microbes to urolithin A (mitochondrial benefit).
Green Tea (EGCG)
Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.
DHEA
Adrenal androgen precursor declining with age; used for adrenal insufficiency and aging.
Licorice Root
Adrenal-supporting herb; chronic high-dose causes pseudo-aldosteronism.
Astaxanthin
Algal carotenoid that is the strongest membrane antioxidant; UV and eye protection.
Bovine Colostrum
First milk rich in IgG, lactoferrin, and growth factors for immune and gut support.
Lactoferrin
Iron-binding protein with antimicrobial and immunomodulating effects.
Alpha-Lipoic Acid (ALA)
Universal antioxidant that's both water and fat soluble — supports glycemic control and nerve health.
Tart Cherry (Montmorency)
Natural melatonin and anthocyanin source — improves sleep and reduces DOMS.
Astaxanthin
Algae-derived xanthophyll — most potent natural antioxidant; UV/eye/skin support.
Ubiquinol (CoQ10)
Reduced active form of CoQ10 — preferred in adults over 40 and those with statin-induced depletion.
Vitamin K2 (MK-7)
Long-half-life K2 — directs calcium to bone and away from arteries.
Astaxanthin (Eye dose)
Carotenoid that crosses BBB and accumulates in ciliary body.
Taurine
Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.
Glutathione
Master intracellular antioxidant; oral bioavailability depends on form.
TUDCA
Bile acid with hepatoprotective effects and ER stress reduction.
Ginkgo Biloba
Vasoactive herb studied for cognition in the elderly and tinnitus.
Shilajit
Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.
Reishi
Adaptogenic mushroom used for immune balance, sleep, and stress.
Quercetin
Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.
TUDCA (Tauroursodeoxycholic Acid)
Conjugated bile acid — hepatoprotective and ER-stress-reducing.
Resveratrol
Polyphenol from grapes — sirtuin activator with mixed human evidence.
Taurine
Conditionally essential amino acid with cardiovascular, metabolic, and longevity effects.
Spirulina
Blue-green algae — protein-rich with phycocyanin antioxidant and immune effects.
Fisetin
Flavonoid senolytic — clears senescent cells in animal models.
Sulforaphane (Broccoli Sprout)
Most potent natural Nrf2 activator — upregulates phase II detox enzymes.
Magnesium L-Threonate
Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.
NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor — popular longevity supplement with growing human data.
Taurine (High-Dose)
Conditionally essential amino acid with longevity and metabolic effects.
Selenium
Trace mineral essential for glutathione peroxidase and thyroid hormone activation.
Cordyceps
Medicinal fungus studied for aerobic capacity and immune modulation.
Shiitake (Lentinan)
Culinary mushroom whose beta-glucan lentinan is an approved injectable immune adjunct.
Olive Leaf Extract
Mediterranean herb with antihypertensive and immune effects.
Bifidobacterium Probiotics
Dominant probiotic genus in the colon; supports immune and gut barrier.
Krill Oil
Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.
Resveratrol
Polyphenol activating sirtuins; bioavailability and clinical effects modest.
Elderberry
Anthocyanin-rich berry used to shorten influenza and URI symptoms.
Echinacea
Native American herb used for URI prevention/duration reduction.
Cranberry
Berry with PACs that inhibit E. coli adhesion to urothelium for UTI prevention.
Urolithin A
Gut-microbial metabolite of ellagitannins — induces mitophagy.
Aged Garlic Extract (Kyolic)
Standardized aged garlic — modest BP and cholesterol benefits.
Hibiscus Tea
Anthocyanin-rich tea with ACE-inhibitor-like blood pressure effects.
Elderberry (Sambucus)
Anthocyanin-rich berry — modest evidence for shortening flu and cold duration.
Vitamin C (Immune Use)
High-dose vit C at symptom onset — modestly shortens cold duration.
L-Carnosine
Histidine dipeptide — anti-glycation and pH buffering.
GlyNAC (Glycine + NAC)
Glycine + NAC combo — restores glutathione in older adults and improves multiple aging markers.
NAC (Lung Support)
Mucolytic and antioxidant — used for COPD exacerbations and idiopathic pulmonary fibrosis.
Zinc Acetate
Lozenge form shown to shorten cold duration when used at first symptoms.
Curcumin Phytosome (Meriva)
Phosphatidylcholine-complexed curcumin — ~29× higher bioavailability than standard extract.
Selenomethionine
Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.
Agaricus blazei
Brazilian mushroom rich in β-glucans for immune modulation.
Maitake D-Fraction
Standardized β-glucan from Grifola frondosa for immune support.
Spirulina (Extra Profile)
Cyanobacterium with phycocyanin for allergy and immunity.
Pterostilbene (Extra)
Methylated resveratrol analog with superior bioavailability.
Tocotrienols (Skin/Aging)
Vitamin E isoforms with 40–60× higher antioxidant power than tocopherols.
Trans-Resveratrol (Pure)
Purified active isomer of resveratrol.
Spermidine (Wheat Germ)
Polyamine that induces autophagy and may extend lifespan.
Urolithin A (Mitopure)
Gut-derived ellagitannin metabolite that induces mitophagy.
Zinc Bisglycinate (High-Bio)
Chelated zinc with superior absorption and tolerability.
Mixed Tocopherols
Full-spectrum natural vitamin E avoiding α-only supplementation pitfalls.
Butterbur
Petasites hybridus extract for migraine prophylaxis and allergic rhinitis.
Cat's Claw
Uncaria tomentosa for joint pain and immunity.
Agaricus Blazei
Brazilian sun mushroom for immune support.
Phellinus Linteus
Meshima mushroom with hispolon for immune support.
Epitalon
Tetrapeptide that activates telomerase.
MOTS-c
Mitochondrial-derived peptide for metabolic regulation.
SS-31 (Elamipretide)
Mitochondrial-targeted peptide for cardiolipin protection.
Glycine + NAC (GlyNAC)
Glutathione-boosting combination for aging.
Rapamycin
mTOR inhibitor studied for longevity (Rx only).
Metformin (Longevity Use)
Biguanide diabetes drug studied for healthspan.
PEA (Palmitoylethanolamide)
Endogenous fatty acid amide for pain and inflammation.
MitoQ
Mitochondria-targeted ubiquinone (CoQ10 analog).
PQQ (Pyrroloquinoline Quinone)
Redox cofactor for mitochondrial biogenesis.
C60 in Olive Oil
Buckminsterfullerene antioxidant.
Ergothioneine (Mushroom-Derived)
Natural ergothioneine from oyster mushrooms.
Hydroxytyrosol
Olive polyphenol for cardiovascular health.
L-Lysine
Essential amino acid for collagen and HSV prevention.
Selenium (Selenomethionine)
Antioxidant trace element for thyroid.
Quercetin Phytosome
Lecithin-complexed quercetin.
Quercetin + Bromelain
Anti-inflammatory pair for allergies.
Stinging Nettle Leaf
Urtica dioica leaf for allergies and joint pain.
Isoquercetin
Highly bioavailable quercetin glycoside.
Luteolin
Flavone with anti-inflammatory effects.
Baicalin
Scutellaria baicalensis flavonoid.
Pelargonium Sidoides
South African geranium for bronchitis.
EPs 7630
Standardized Pelargonium extract.
Echinacea Purpurea
Coneflower for upper respiratory infections.
Echinacea Angustifolia
Narrow-leaf coneflower for immune support.
Lion's Mane Fruiting Body
Hericinones-rich beta-glucan source.
Agarikon (Fomitopsis officinalis)
Antiviral polypore mushroom.
Poria Cocos
TCM mushroom for sleep and immunity.
Oyster Mushroom
Pleurotus ostreatus with ergothioneine.
Butterbur Ze 339
PA-free butterbur for allergic rhinitis.
Marshmallow Root
Althaea officinalis mucilage for cough.
Trans-Resveratrol
Active form of resveratrol.
Micronized Resveratrol
Improved bioavailability resveratrol.
Punicalagin
Major pomegranate ellagitannin.
Ellagic Acid
Ellagitannin hydrolysis product.
Cranberry Extract
Vaccinium macrocarpon for UTI prevention.
Olive Leaf (Standardized Oleuropein)
High-oleuropein extract.
Lauric Acid
Coconut MCFA with antimicrobial activity.
Black Seed Oil (Nigella sativa)
Thymoquinone for immune and metabolic health.
Thymoquinone
Active black seed compound.
Propolis
Bee glue with caffeic acid phenethyl ester.
Bee Pollen
Pollen collected by bees.
Manuka Honey
Leptospermum honey with MGO.
Bromelain
Pineapple proteolytic enzyme.
Ginger Extract (Zingiber)
Standardized ginger for nausea and inflammation.
Galangal (Alpinia)
Thai ginger relative for inflammation.
Holy Basil (Tulsi)
Ocimum sanctum adaptogen.
Holy Basil Eugenol
Active constituent of tulsi.
Honokiol
Active magnolia compound.
Liposomal Vitamin C
Phospholipid-encapsulated vitamin C.
Ascorbyl Palmitate
Fat-soluble vitamin C ester.
Sodium Ascorbate
Buffered vitamin C form.
Bovine Colostrum
First milk with growth factors.
Chlorella
Green algae with chlorophyll.
Amla (Indian Gooseberry)
Phyllanthus emblica vitamin C source.
Black Cumin Seed Oil
Nigella sativa oil.
Oleocanthal
EVOO ibuprofen-like compound.
Lion's Mane
Edible medicinal mushroom that upregulates NGF and BDNF — studied for nerve growth and cognition.
Eleuthero
Adaptogen used to support stamina, immune function, and stress resilience.
Fisetin
Flavonoid studied as senolytic — clearing senescent cells in animal models.
Quercetin
Flavonoid with antihistamine, anti-viral, and senolytic activity.
Tocotrienols (Vitamin E)
Unsaturated vitamin E family — superior antioxidant capacity vs alpha-tocopherol.
Lithium Orotate (low-dose)
Low-dose lithium salt studied for mood stability and neuroprotection.
Chaga
Birch-tree mushroom rich in melanin, betulin, and antioxidants.
PQQ
Cofactor stimulating mitochondrial biogenesis (PGC-1α).
Pterostilbene
Bioavailable resveratrol analog with longer half-life.
Spermidine
Polyamine inducing autophagy; epidemiologic association with longevity.
Monolaurin
Coconut-derived monoglyceride with antimicrobial properties against enveloped viruses.
ALCAR + ALA (Mitochondrial Protection)
Mitochondrial antioxidant stack — popularized as harm-reduction adjunct for MDMA neuroprotection.
EGCG (Green Tea Catechin)
Potent CYP/COMT-modulating antioxidant — popularized in MDMA harm-reduction stacks.
Vitamin C (Harm-Reduction Antioxidant)
Water-soluble antioxidant — quenches dopamine quinone and other reactive metabolites.
Pterostilbene
Methylated analog of resveratrol — better bioavailability and longer half-life.
Spermidine
Polyamine that induces autophagy — emerging longevity supplement.
Ergothioneine
Unique antioxidant from mushrooms with its own transporter — accumulates in oxidative-stress tissues.
Zinc Picolinate
Zinc chelated to picolinic acid — one of the most bioavailable oral forms.
Zinc Bisglycinate
Glycine-chelated zinc — high absorption and very gentle on the stomach.
Liposomal Glutathione
Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.
S-Acetyl Glutathione
Acetylated GSH — stable through the gut and converted intracellularly to glutathione.
9-Me-BC
β-carboline alkaloid that upregulates dopamine neurons in animal models.
Centrophenoxine
Cholinergic precursor that reduces lipofuscin accumulation in neurons.
Chinese Skullcap
Flavonoid-rich root used for anxiety and inflammation.
Thymulin (Reference)
Zinc-dependent thymic peptide that matures T-cells.
Alpha-Ketoglutarate (AKG)
TCA-cycle intermediate studied for healthspan and frailty.
Fisetin (Senolytic)
Polyphenol senolytic with neuroprotective and anti-inflammatory effects.
Quercetin + Dasatinib (D+Q)
Reference senolytic combination cycled to clear senescent cells.
L-Carnosine
Dipeptide that buffers protons and reduces advanced glycation end-products.
Ergothioneine (Extra)
Unique thiol antioxidant concentrated in mitochondria via OCTN1.
Calcium AEP (Membrane Calcium)
Cell-membrane-targeted form of calcium claimed for autoimmune support.