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evidence · mechanism · dose
Supplements/Vitamin

Sodium Ascorbate

Buffered vitamin C form.

Immune Function

Overview

Buffered vitamin C form.

Natural sources
    Common forms

      Mechanism of action

      Neutral pH; better GI tolerance.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        High-dose vitamin C

        Moderate evidence

        Potential side effects

        Common
        • · Sodium load
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid with these conditions
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Immunosuppressants

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1000–4000 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Vitamin
            Sodium Ascor…
            Amazon
            Wide selection · fast shipping
            Vitamin
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            iHerb
            Global delivery · curated brands
            Vitamin
            Sodium Ascor…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewJ Nutr Environ Med · 2008

            Buffered vitamin C tolerance

            Hickey S, et al.

            Clinical review

            Key findings

            Better tolerated at high doses.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Ascorbate — High-dose vitamin C

            Live PubMed search

            Live results for "Sodium Ascorbate High-dose vitamin C" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Ascorbate and "High-dose vitamin C". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Ascorbate — randomized controlled trial

            Live PubMed search

            Live results for "Sodium Ascorbate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Ascorbate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Ascorbate — meta-analysis

            Live PubMed search

            Live results for "Sodium Ascorbate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Ascorbate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Ascorbate — pharmacokinetics

            Live PubMed search

            Live results for "Sodium Ascorbate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Ascorbate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Ascorbate — safety adverse events

            Live PubMed search

            Live results for "Sodium Ascorbate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Ascorbate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Ascorbate — dose response

            Live PubMed search

            Live results for "Sodium Ascorbate dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Ascorbate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Sodium Ascorbate — clinical evidence

            Live Scholar search

            Cross-database citation index for Sodium Ascorbate as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.