Overview
Low-dose lithium salt studied for mood stability and neuroprotection.
- Drinking water (trace)
- Some grains
- Lithium orotate
- Lithium carbonate (Rx)
Mechanism of action
Inhibits GSK-3β and inositol monophosphatase; increases BDNF.
- · GSK-3β inhibition
- · Wnt signaling
- · BDNF
Effects on the body
Organ system effects
Low-dose may reduce suicide risk at population level (ecological).
Evidence-based benefits
Reduces aggressive/impulsive symptoms (small trials)
Limited evidencePotential side effects
- · Nausea
- · Tremor
- · Lithium toxicity (rare at <20 mg elemental)
Drug interactions
Supplement interactions
None listed.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Scientific evidence (8)
Lithium Orotate (low-dose): pharmacology, clinical evidence, and safety — narrative review
Examine.com Research Team
Curated narrative review of human and preclinical evidence for Lithium Orotate (low-dose), including mechanism, typical dosing, and safety considerations.
Best-supported outcome: Reduces aggressive/impulsive symptoms (small trials) (evidence: limited). Additional outcomes and limitations summarized in the full profile.
PubMed: Lithium Orotate (low-dose) — Reduces aggressive/impulsive symptoms
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PubMed: Lithium Orotate (low-dose) — randomized controlled trial
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PubMed: Lithium Orotate (low-dose) — meta-analysis
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PubMed: Lithium Orotate (low-dose) — pharmacokinetics
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PubMed: Lithium Orotate (low-dose) — safety adverse events
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PubMed: Lithium Orotate (low-dose) — dose response
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Google Scholar: Lithium Orotate (low-dose) — clinical evidence
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Cross-database citation index for Lithium Orotate (low-dose) as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.