Overview
Water-soluble antioxidant — quenches dopamine quinone and other reactive metabolites.
Mechanism of action
Recycles other antioxidants; scavenges ROS generated during catecholamine metabolism.
Effects on the body
Organ system effects
Evidence-based benefits
Reduced amphetamine-induced neurotoxicity (animal)
Limited evidencePotential side effects
- · Loose stools at high dose
Drug interactions
No notable interactions reported.
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
- ·Discuss with a clinician if you have active liver disease or take hepatotoxic medications.
Supplement interactions
None listed.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.
Scientific evidence (8)
Vitamin C and oxidative stress reduction
Padayatty SJ, et al.
Review of vitamin C's antioxidant roles.
Reduces lipid peroxidation and oxidative damage markers.
PubMed: Vitamin C (Harm-Reduction Antioxidant) — Reduced amphetamine-induced neurotoxicity
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PubMed: Vitamin C (Harm-Reduction Antioxidant) — randomized controlled trial
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PubMed: Vitamin C (Harm-Reduction Antioxidant) — meta-analysis
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PubMed: Vitamin C (Harm-Reduction Antioxidant) — pharmacokinetics
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PubMed: Vitamin C (Harm-Reduction Antioxidant) — safety adverse events
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PubMed: Vitamin C (Harm-Reduction Antioxidant) — dose response
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Google Scholar: Vitamin C (Harm-Reduction Antioxidant) — clinical evidence
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