Overview
Bitter herb with strong RCT evidence for URI symptom reduction.
- Andrographis paniculata
- Standardized andrographolides
Forms & variants of Andrographis
Different chemical forms of Andrographis behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Andrographolides modulate NF-κB and inhibit viral replication.
- · NF-κB modulation
Effects on the body
Organ system effects
Reduces cold severity and duration.
Evidence-based benefits
Reduces URI symptom severity and duration
Strong evidencePotential side effects
- · Bitter taste
- · GI upset
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
- PregnancyPossible abortifacient.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Andrographis — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Andrographis third party tested NSF
CapsulesPre-measured Andrographis capsules — easiest for travel and consistent daily dosing without scoops or scales.Andrographis capsules
PowderBulk unflavored Andrographis powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Andrographis powder unflavored
Best sellersMost-purchased Andrographis products on Amazon — a quick way to see what's reviewed widely before you commit.Andrographis best sellerScientific evidence8Show studiesHide studies
Andrographis paniculata for respiratory tract infections
Hu XY, et al.
Meta-analysis of 33 RCTs.
Reduced symptom severity and duration in URTI.
PubMed: Andrographis — Reduces URI symptom severity and duration
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PubMed: Andrographis — randomized controlled trial
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PubMed: Andrographis — meta-analysis
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PubMed: Andrographis — pharmacokinetics
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PubMed: Andrographis — safety adverse events
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PubMed: Andrographis — dose response
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Google Scholar: Andrographis — clinical evidence
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Cross-database citation index for Andrographis as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.