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evidence · mechanism · dose
Supplements/Herb

Andrographis

aka Andrographis paniculata

Bitter herb with strong RCT evidence for URI symptom reduction.

Immune Function

Overview

Bitter herb with strong RCT evidence for URI symptom reduction.

Natural sources
  • Andrographis paniculata
Common forms
  • Standardized andrographolides

Forms & variants of Andrographis

Different chemical forms of Andrographis behave differently. Browse each form's mechanism, bioavailability, and best-use context.

KalmCold standardized
Andrographis (KalmCold)

Standardized andrographolide for acute upper respiratory infections.

Mechanism of action

Andrographolides modulate NF-κB and inhibit viral replication.

Pathways
  • · NF-κB modulation

Effects on the body

Decreases
URI symptoms and duration

Organ system effects

Immune System

Reduces cold severity and duration.

Evidence-based benefits

Reduces URI symptom severity and duration

Strong evidence

Potential side effects

Common
  • · Bitter taste
  • · GI upset
Rare
    Serious

      Drug interactions

      Anticoagulants / antihypertensives / antidiabetics
      Additive effects.
      moderate

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with
      • Pregnancy
        Possible abortifacient.

      Dosing & bioavailability

      Typical dose
      200–400 mg standardized × 3/d during illness

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Herb
      Andrographis
      Amazon
      Wide selection · fast shipping
      Herb
      Andrographis
      iHerb
      Global delivery · curated brands
      Herb
      Andrographis
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      Meta-analysisPLoS One · 2017

      Andrographis paniculata for respiratory tract infections

      Hu XY, et al.

      Meta-analysis of 33 RCTs.

      Key findings

      Reduced symptom severity and duration in URTI.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Andrographis — Reduces URI symptom severity and duration

      Live PubMed search

      Live results for "Andrographis Reduces URI symptom severity and duration" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Andrographis and "Reduces URI symptom severity and duration". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Andrographis — randomized controlled trial

      Live PubMed search

      Live results for "Andrographis randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Andrographis and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Andrographis — meta-analysis

      Live PubMed search

      Live results for "Andrographis meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Andrographis and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Andrographis — pharmacokinetics

      Live PubMed search

      Live results for "Andrographis pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Andrographis and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Andrographis — safety adverse events

      Live PubMed search

      Live results for "Andrographis safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Andrographis and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Andrographis — dose response

      Live PubMed search

      Live results for "Andrographis dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Andrographis and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Andrographis — clinical evidence

      Live Scholar search

      Cross-database citation index for Andrographis as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.