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evidence · mechanism · dose
Supplements/Herb

Andrographis (KalmCold)

Standardized andrographolide for acute upper respiratory infections.

Immune Function

Overview

Standardized andrographolide for acute upper respiratory infections.

Natural sources
    Common forms

      Forms & variants of Andrographis

      Different chemical forms of Andrographis behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Andrographis

      Bitter herb with strong RCT evidence for URI symptom reduction.

      Parent
      Andrographis Paniculata

      Bitter herb with strong evidence for cold symptom reduction.

      Mechanism of action

      Modulates NF-κB, cytokine release, and immune cell trafficking.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Shortens URI duration

        Strong evidence

        Potential side effects

        Common
        • · GI upset
        • · Skin rash
        Rare
        • · Hepatotoxicity (chronic high dose)
        Serious

          Drug interactions

          Anticoagulants
          Antiplatelet effect.
          moderate
          Immunosuppressants
          Antagonism.
          moderate

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)
          Avoid with these conditions
          • ·Autoimmune disease (theoretical immune activation)
          Avoid / monitor with these medications
          • ·Immunosuppressants

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          200 mg KalmCold
          With food?
          With food

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Herb
          Andrographis…
          Amazon
          Wide selection · fast shipping
          Herb
          Andrographis…
          iHerb
          Global delivery · curated brands
          Herb
          Andrographis…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTPhytomedicine · 2010

          KalmCold for URI

          Saxena RC, et al.

          5-day DB-RCT in 223 URI patients.

          Key findings

          Significant symptom improvement vs placebo by day 3.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Andrographis (KalmCold) — Shortens URI duration

          Live PubMed search

          Live results for "Andrographis (KalmCold) Shortens URI duration" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Andrographis (KalmCold) and "Shortens URI duration". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Andrographis (KalmCold) — randomized controlled trial

          Live PubMed search

          Live results for "Andrographis (KalmCold) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Andrographis (KalmCold) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Andrographis (KalmCold) — meta-analysis

          Live PubMed search

          Live results for "Andrographis (KalmCold) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Andrographis (KalmCold) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Andrographis (KalmCold) — pharmacokinetics

          Live PubMed search

          Live results for "Andrographis (KalmCold) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Andrographis (KalmCold) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Andrographis (KalmCold) — safety adverse events

          Live PubMed search

          Live results for "Andrographis (KalmCold) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Andrographis (KalmCold) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Andrographis (KalmCold) — dose response

          Live PubMed search

          Live results for "Andrographis (KalmCold) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Andrographis (KalmCold) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Andrographis (KalmCold) — clinical evidence

          Live Scholar search

          Cross-database citation index for Andrographis (KalmCold) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.