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evidence · mechanism · dose
Supplements/Herb

Andrographis (KalmCold)

Standardized andrographolide for acute upper respiratory infections.

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Immune Function

Overview

Standardized andrographolide for acute upper respiratory infections.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Forms & variants of Andrographis

Different chemical forms of Andrographis behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Parent
Andrographis

Bitter herb with strong RCT evidence for URI symptom reduction.

Parent
Andrographis Paniculata

Bitter herb with strong evidence for cold symptom reduction.

Mechanism of action

Modulates NF-κB, cytokine release, and immune cell trafficking.

Pathways
  • · Modulates NF-κB, cytokine release
  • · and immune cell trafficking

Effects on the body

Supports
Shortens URI duration

Organ system effects

Immune System

Andrographis (KalmCold) modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Evidence-based benefits

Shortens URI duration

Strong evidence

Potential side effects

Common
  • · GI upset
  • · Skin rash
Rare
  • · Hepatotoxicity (chronic high dose)
Serious

    Drug interactions

    Anticoagulants
    Antiplatelet effect.
    moderate
    Immunosuppressants
    Antagonism.
    moderate

    Safety & non-supplemental interactions

    Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

    Avoid if you are
    • ·Pregnant or breastfeeding (insufficient safety data)
    • ·Children under 18 (unless directed by a clinician)
    Avoid with these conditions
    • ·Autoimmune disease (theoretical immune activation)
    Avoid / monitor with these medications
    • ·Immunosuppressants

    Supplement interactions

    Pairs well with
    • Vitamin D3 + K2
      Foundational immune modulation.
    • Zinc
      Required cofactor for innate and adaptive immune function.
    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    200 mg KalmCold
    Best form
    Most evidence is based on the standardized extract capsule form.
    Timing
    Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
    With food?
    With food

    Where to buy

    Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

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    Scientific evidence8Show studies
    RCTPhytomedicine · 2010

    KalmCold for URI

    Saxena RC, et al.

    5-day DB-RCT in 223 URI patients.

    Key findings

    Significant symptom improvement vs placebo by day 3.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Andrographis (KalmCold) — Shortens URI duration

    Live PubMed search

    Live results for "Andrographis (KalmCold) Shortens URI duration" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Andrographis (KalmCold) and "Shortens URI duration". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Andrographis (KalmCold) — randomized controlled trial

    Live PubMed search

    Live results for "Andrographis (KalmCold) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Andrographis (KalmCold) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Andrographis (KalmCold) — meta-analysis

    Live PubMed search

    Live results for "Andrographis (KalmCold) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Andrographis (KalmCold) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Andrographis (KalmCold) — pharmacokinetics

    Live PubMed search

    Live results for "Andrographis (KalmCold) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Andrographis (KalmCold) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Andrographis (KalmCold) — safety adverse events

    Live PubMed search

    Live results for "Andrographis (KalmCold) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Andrographis (KalmCold) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Andrographis (KalmCold) — dose response

    Live PubMed search

    Live results for "Andrographis (KalmCold) dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Andrographis (KalmCold) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Andrographis (KalmCold) — clinical evidence

    Live Scholar search

    Cross-database citation index for Andrographis (KalmCold) as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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