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evidence · mechanism · dose
Supplements/Herb

Pelargonium sidoides (Umckaloabo)

South African geranium root for acute bronchitis and URIs.

Immune Function

Overview

South African geranium root for acute bronchitis and URIs.

Natural sources
    Common forms

      Mechanism of action

      Antiviral and antibacterial; enhances phagocytosis and ciliary beat frequency.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces severity and duration of acute bronchitis

        Strong evidence

        Potential side effects

        Common
        • · GI upset
        Rare
        • · Hepatotoxicity (rare reports)
        Serious

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)
          Avoid with these conditions
          • ·Autoimmune disease (theoretical immune activation)
          Avoid / monitor with these medications
          • ·Immunosuppressants

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          30 drops tid / 20 mg tid
          With food?
          With meals

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Herb
          Pelargonium …
          Amazon
          Wide selection · fast shipping
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          iHerb
          Global delivery · curated brands
          Herb
          Pelargonium …
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTCurr Med Res Opin · 2010

          EPs 7630 in acute bronchitis

          Matthys H, et al.

          7-day DB-RCT in 405 adults.

          Key findings

          Significantly reduced bronchitis severity score vs placebo.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Pelargonium sidoides (Umckaloabo) — Reduces severity and duration of acute bronchitis

          Live PubMed search

          Live results for "Pelargonium sidoides (Umckaloabo) Reduces severity and duration of acute bronchitis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Pelargonium sidoides (Umckaloabo) and "Reduces severity and duration of acute bronchitis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Pelargonium sidoides (Umckaloabo) — randomized controlled trial

          Live PubMed search

          Live results for "Pelargonium sidoides (Umckaloabo) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Pelargonium sidoides (Umckaloabo) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Pelargonium sidoides (Umckaloabo) — meta-analysis

          Live PubMed search

          Live results for "Pelargonium sidoides (Umckaloabo) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Pelargonium sidoides (Umckaloabo) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Pelargonium sidoides (Umckaloabo) — pharmacokinetics

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          Live results for "Pelargonium sidoides (Umckaloabo) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

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          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Pelargonium sidoides (Umckaloabo) — safety adverse events

          Live PubMed search

          Live results for "Pelargonium sidoides (Umckaloabo) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

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          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Pelargonium sidoides (Umckaloabo) — dose response

          Live PubMed search

          Live results for "Pelargonium sidoides (Umckaloabo) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Pelargonium sidoides (Umckaloabo) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Pelargonium sidoides (Umckaloabo) — clinical evidence

          Live Scholar search

          Cross-database citation index for Pelargonium sidoides (Umckaloabo) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.